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Updated: Jul 11, 2025

Techniques to Induce and Quantify Cellular Senescence
06:51

Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

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Lifestyle interventions to delay senescence

Jan Martel1, David M Ojcius2, John D Young3

  • 1Center for Molecular and Clinical Immunology, Chang Gung University, Taoyuan, Taiwan.

Biomedical Journal
|November 4, 2023
PubMed

Insights

Lifestyle interventions like exercise and diet can reduce cellular senescence, a key driver of aging and chronic diseases. These strategies offer a natural approach to combat age-related inflammation and promote health.

Area of Science:

  • Gerontology and cellular biology.
  • Investigating the biological mechanisms of aging.

Background:

  • Cellular senescence, a state of irreversible cell cycle arrest, is linked to increased inflammation and chronic diseases.
  • Senolytics and senomorphics show promise, but lifestyle interventions are under-explored.

Purpose of the Study:

  • To review the impact of various lifestyle interventions on cellular senescence.
  • To highlight natural approaches for mitigating age-related decline.

Main Methods:

  • Literature review of studies on exercise, nutrition, caloric restriction, intermittent fasting, phytochemicals, prebiotics, probiotics, and sleep.
  • Analysis of effects in model organisms and human subjects.

Main Results:

  • Multiple lifestyle factors demonstrably reduce cellular senescence and associated inflammation.
  • These interventions show potential in delaying age-related disease development.

Conclusions:

  • Lifestyle interventions offer a viable strategy to manage cellular senescence and inflammation.
  • Integrating these practices can promote healthy aging and reduce chronic disease burden.
Keywords:
Caloric restrictionExerciseMetforminNutritionPhytochemicalsSenescence

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