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Plasma metabolomics and quantitative interstitial abnormalities in ever-smokers
Bina Choi1,2, Raúl San José Estépar3,4, Suneeta Godbole5
1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, 75 Francis Street, Pulmonary-PBB-CA-3, Boston, MA, 02115, USA. bchoi4@bwh.harvard.edu.
This study identifies specific plasma metabolites linked to quantitative interstitial abnormalities (QIA) in smokers, offering insights into early lung disease. These findings highlight metabolic pathways involved in inflammation and tissue remodeling, differentiating QIA from emphysema.
Area of Science:
- Pulmonary Medicine
- Metabolomics
- Radiology
Background:
- Quantitative interstitial abnormalities (QIA) are CT findings indicating early lung disease in smokers, linked to poor health outcomes.
- The metabolic changes associated with QIA are not well understood.
- This study investigates plasma metabolites in relation to QIA and emphysema in smokers.
Purpose of the Study:
- To identify plasma metabolites associated with QIA in smokers.
- To compare metabolomic profiles of QIA and emphysema.
Main Methods:
- Analyzed plasma samples from 928 smokers using liquid chromatography-mass spectrometry.
- Assessed associations between metabolites and QIA/emphysema using multivariable and multinomial regression models.
- Performed pathway enrichment analysis to understand biological relevance.
Main Results:
- Identified 85 metabolites associated with QIA, enriched in pathways like nicotinate/nicotinamide and histidine.
- Found 75 metabolites differentiating QIA-predominant from emphysema-predominant phenotypes, enriched in pathways like phosphatidylethanolamine and aminoacyl-tRNA.
- Associated metabolites relate to inflammation, ECM remodeling, and muscle cachexia.
Conclusions:
- Plasma metabolomics provides insights into the biological underpinnings of QIA in smokers.
- Metabolite profiles can help differentiate QIA from emphysema, aiding in understanding smoking-related lung diseases.
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