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Updated: Jul 11, 2025
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
One-year lung function decline in sarcoidosis
Kiminobu Tanizawa1, Tomohiro Handa2, Sonoko Nagai3
1Department of Respiratory Medicine, Japan.
Background:
The definition of progressive pulmonary fibrosis is based on a 1-year lung function decline.
Objectives:
To evaluate the epidemiology and clinical relevance of 1-year lung function decline in sarcoidosis.
Methods:
A retrospective observational study at a general sarcoidosis clinic.
Results:
Of the 198 patients, 42 (18.4 %) had a 1-year lung function decline (absolute 12-month decline in percentage predicted forced vital capacity [%FVC] of ≥5 % or percentage predicted diffusion capacity for carbon monoxide [%DLCO] of ≥10 %). A 1-year lung function decline was associated with a 2-year lung function decline (a relative 24-month decline in %FVC of ≥10 % or %DLCO of ≥15 %), which occurred in 13 (7.4 %) of the 175 patients with 24-month follow-up results. A 1-year lung function decline was not associated with survival; a 2-year lung function decline predicted mortality.
Conclusions:
Compared with a 24-month decline, a 12-month decline in lung function did not predict worse survival in sarcoidosis.
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