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Updated: Jul 11, 2025

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One-year lung function decline in sarcoidosis.

Kiminobu Tanizawa1, Tomohiro Handa2, Sonoko Nagai3

  • 1Department of Respiratory Medicine, Japan.

Respiratory Investigation
|November 5, 2023
PubMed
Summary

A 1-year lung function decline in sarcoidosis patients did not predict mortality. However, a 2-year decline in lung function was associated with increased mortality risk in sarcoidosis.

Keywords:
Lung functionProgressive fibrosing interstitial lung diseaseProgressive pulmonary fibrosisSarcoidosisSurvival

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Area of Science:

  • Pulmonary Medicine
  • Respiratory Research

Background:

  • Progressive pulmonary fibrosis is defined by a 1-year lung function decline.
  • Investigating lung function changes in sarcoidosis is crucial for understanding disease progression.

Purpose of the Study:

  • To assess the occurrence and clinical significance of a 1-year lung function decline in sarcoidosis patients.
  • To determine if early lung function decline predicts long-term outcomes in sarcoidosis.

Main Methods:

  • Retrospective observational study conducted at a specialized sarcoidosis clinic.
  • Analysis of lung function parameters including forced vital capacity (FVC) and diffusion capacity for carbon monoxide (DLCO).

Main Results:

  • 18.4% of sarcoidosis patients experienced a 1-year lung function decline (≥5% predicted FVC or ≥10% predicted DLCO).
  • A 1-year decline was linked to a 2-year decline (≥10% FVC or ≥15% DLCO), observed in 7.4% of patients.
  • A 1-year lung function decline did not correlate with survival, but a 2-year decline predicted mortality.

Conclusions:

  • A 12-month lung function decline is not a predictor of worse survival in sarcoidosis.
  • Longer-term lung function decline (24 months) is associated with increased mortality risk in sarcoidosis.