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Study of Allergy and Sensitization Relationship in Children and Parents in Southern China
Hui Gan1, Zhifeng Huang2, Huiqing Zhu2
1Department of Clinical Laboratory, The Key Laboratory of Advanced Interdisciplinary Studies Center, The First Affiliated Hospital of Guangzhou Medical University, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, Guangzhou, China, hustgh@hotmail.com.
Insights
Parental allergies significantly increase children's allergy risk. Paternal allergies impact children's quality of life, highlighting the importance of family history in pediatric allergy assessment.
Area of Science:
- Pediatric Allergy and Immunology
- Genetics of Allergic Diseases
- Environmental Health
Background:
- Global rise in allergic disease incidence.
- Genetics is a key factor in allergy development.
- Limited understanding of parental influence on childhood allergies.
Purpose of the Study:
- Investigate the correlation between parental allergy status and childhood allergies.
- Assess the impact of parental allergies on children's allergy symptoms and quality of life.
Main Methods:
- Electronic questionnaires for allergy symptoms in children and parents.
- Clinical diagnosis, serum allergen-specific immunoglobulin E (IgE), total IgE, and blood cell counts.
- Analysis of 88 family groups.
Main Results:
- High allergy prevalence: 85.2% in children, 50% in fathers, 42% in mothers.
- Paternal allergies correlated with higher child allergy diagnosis and sensitization rates.
- Paternal allergies negatively affected children's quality of life due to allergic rhinitis.
Conclusions:
- Positive correlation between childhood and parental allergies.
- Further research is needed to confirm these findings.
- Paternal allergy status is a significant factor in pediatric allergy outcomes.
Introduction:
The incidence of allergic diseases has increased globally, with genetics playing an essential role in these conditions' development. However, there is still a gap in understanding of how parental allergy status affects children's allergies.
Methods:
An electronic questionnaire was used to assess allergy-related symptoms in kindergarten children and their parents, with a clinical diagnosis and concurrent serum allergen-specific immunoglobulin E (IgE), total IgE, and blood cell counts obtained.
Results:
88 family groups were enrolled, with allergy prevalence of 85.2% in children, 50% in fathers, and 42% in mothers. Allergic rhinoconjunctivitis was the most common allergic disease. When the mother had an allergy, the children's allergy diagnosis rate was 91.3%; 86.67% when the father had an allergy; and 85.71% when both parents had allergies. The child sensitization rate was 78.26% when the father had sensitization, 59.09% just as the mother had sensitization, and 84.21% when both parents had sensitization. Paternal allergies affected children's quality of life due to allergic rhinitis but not their rhinitis symptoms. Maternal allergies or sensitization did not significantly affect children's symptoms or quality-of-life scores.
Conclusion:
The study found a positive correlation between childhood and parental allergies, and further studies are needed to confirm the findings.
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