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Bone marrow adipocyte: Origin, biology and relationship with hematological malignancy
Yan Wang1,2,3, Chunxia Yang4,5, Junzhao Wan6
1Department of Hematology, Affiliated Hospital of Guizhou Medical University, Guiyang, China.
International Journal of Laboratory Hematology
|November 5, 2023
Summary
Bone marrow adipose tissue (BMAT) accumulates throughout life and differs from other fat tissues. Bone marrow adipocytes play complex roles in hematopoiesis, cancer progression, and chemotherapy resistance.
Area of Science:
- Biomedical Science
- Cell Biology
- Hematology
Background:
- Bone marrow adipose tissue (BMAT) is a recognized histological component.
- Understanding the role of BMAT in physiological and pathological processes is crucial.
Purpose of the Study:
- To quantitatively analyze keyword clusters related to BMAT and hematopoiesis.
- To elucidate the distinct characteristics and functions of bone marrow adipocytes (BMAds).
Main Methods:
- Bibliometric analysis of keywords.
- Quantitative analysis of BMAT and hematopoiesis literature.
Main Results:
- BMAds are distinct from extramedullary adipose tissues and accumulate dynamically throughout life.
- BMAds are involved in normal hematopoiesis and positively influence hematologic malignancies.
- BMAds contribute to chemotherapy resistance via metabolic reprogramming and altered secretory profiles.
Conclusions:
- BMAT plays a multifaceted role in bone marrow homeostasis and disease.
- BMAds exhibit complex interactions with hematopoiesis and hematologic malignancies.
- BMAds represent a potential target for understanding and overcoming chemotherapy resistance.
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