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Bacterial Signaling

Bacterial Signaling

Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...

Gene Regulation in Microbial Communities: Quorum Sensing

Gene Regulation in Microbial Communities: Quorum Sensing

Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...

Global Regulatory Systems

Global Regulatory Systems

Global regulatory systems in bacteria enable rapid and coordinated responses to environmental changes by integrating sensory inputs with gene expression, ensuring efficient adaptation to fluctuating conditions. Key global regulatory mechanisms include regulons, two-component systems, sigma factors, and secondary messengers.Regulons and Global RegulatorsA regulon is a collection of genes and operons controlled by a common global regulator. These regulators enable bacteria to prioritize resource...

Biofilms

Biofilms

Biofilms are complex communities of microorganisms encased in a self-produced extracellular polysaccharide matrix attached to surfaces. These microbial consortia can include single or multiple species, providing enhanced survival benefits by forming organized, multilayered structures.The formation of biofilms occurs through four key stages: attachment, colonization, development, and dispersal.During attachment, free-swimming planktonic cells adhere to a surface, often facilitated by...

Yeast Signaling

Yeast Signaling

Yeasts are single-celled organisms, but unlike bacteria, they are eukaryotes (cells with a nucleus). Cell signaling in yeast is similar to signaling in other eukaryotic cells. A ligand, such as a protein or a small molecule released from a yeast cell, attaches to a receptor on the cell surface. The binding stimulates second-messenger kinases to activate or inactivate transcription factors that further regulate gene expression. Many of the yeast intracellular signaling cascades have similar...

Coordination of Gene Expression Processes in Bacteria

Coordination of Gene Expression Processes in Bacteria

The DNA replication, transcription, and translation processes are intricately coupled in bacteria, allowing efficient gene expression and rapid protein synthesis. While this physical and functional coordination is advantageous, it introduces challenges that bacteria overcome through specific regulatory mechanisms.Coupling of Replication, Transcription, and TranslationThe coupling of replication, transcription, and translation is a hallmark of bacterial gene expression. As the replisome unwinds...

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Related Experiment Video

Updated: Jul 11, 2025

Time-lapse Imaging of Bacterial Swarms and the Collective Stress Response

Time-lapse Imaging of Bacterial Swarms and the Collective Stress Response

Published on: May 23, 2020

Bacterial quorum sensing orchestrates longitudinal interactions to shape microbiota assembly.

Ying Su^1,2, Ming-Ying Xu^1,3, Ying Cui^1,2

¹Department of Immunology and Microbiology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, 510080, China.

|November 5, 2023

Summary

Bacterial quorum sensing (QS) networks regulate oral microbiota assembly. Interfering with these QS networks alters microbial community structure and maturity, offering new manipulation strategies.

Keywords:

Bacterial communication Bacterial interaction Interspecies cross-talk Microbiota assembly Microbiota manipulation Quorum sensing

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Last Updated: Jul 11, 2025

Time-lapse Imaging of Bacterial Swarms and the Collective Stress Response

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Published on: May 23, 2020

Anti-virulent Disruption of Pathogenic Biofilms using Engineered Quorum-quenching Lactonases

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Published on: January 1, 2016

Assembly and Tracking of Microbial Community Development within a Microwell Array Platform

Assembly and Tracking of Microbial Community Development within a Microwell Array Platform

Published on: June 6, 2017

Area of Science:

Microbiome Research
Microbial Ecology
Systems Biology

Background:

Microbiota assembly mechanisms are crucial for understanding and manipulating microbial communities.
Bacterial quorum sensing (QS) is a key intercellular communication system with potential roles in microbiota assembly.
The regulatory role of QS in human microbiota assembly remains largely unexplored.

Discussion:

A novel in vitro oral biofilm microbiota assembling (OBMA) model was developed to study time-series assembly.
The study identified a longitudinal QS network with sequentially enriched QS pathways and hubs.
QS network cross-talk influences microbial community structure and assembly dynamics.

Key Insights:

Discovered 2291 QS protein homologues across 21 QS pathways, many newly reported and sequentially enriched.
Identified key QS hubs (e.g., Streptococcus, Veillonella-Megasphaera, Prevotella-Fusobacteria) forming a longitudinal network.
QS interference experiments validated the network's predictive and manipulative power on OBM assembly.

Outlook:

The findings provide a new perspective on the mechanisms of complex microbiota assembly.
This research offers a theoretical foundation for precise human microbiota manipulation via QS network intervention.
Further studies can explore QS-based interventions for targeted microbiome modulation.