Related Experiment Video
Updated: Aug 15, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
Pembrolizumab-Induced Nodular Posterior Scleritis
Calvin L McNelly1, Asghar A Haider1,2, Robert C Wann1,2
1University of Alabama Callahan Eye Hospital and Clinics, Birmingham, AL, USA.
Abstract:
Purpose: To report a case of painless posterior scleritis presenting as a choroidal nodule in a patient with history of a tumor being treated with pembrolizumab. Methods: A case and its findings were analyzed, and a relevant literature review was performed. Results: A 20-year-old woman with a history of ependymoma presented with painless blurred vision in the right eye after being started on pembrolizumab for a tumor recurrence. Fundoscopy showed a solitary amelanotic choroidal lesion with surrounding subretinal fluid in the affected eye. Ultrasonography showed moderate internal reflectivity and fluid in Tenon capsule consistent with nodular posterior scleritis. After a course of systemic steroids and discontinuation of the pembrolizumab, the choroidal lesion completely resolved. Conclusions: Clinicians should be aware of posterior scleritis as an ocular complication of this class of medications.
Related Concept Videos
Alzheimer Disease l: Introduction
Alzheimer Disease ll: Pathophysiology
Huntington Disease l: Introduction
Degenerative Disc Disease ll: Pathophysiology
Alterations in Muscle Tone lll
Secondary Spinal Cord Injury llI: Pathophysiology

