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Comprehensive analysis of the relationship between xanthine oxidoreductase activity and chronic kidney disease

Yiyuan Zhang1, Xiaobao Ding1,2, Lihao Guo1

  • 1Department of Nephrology, The Affiliated Huai'an Hospital of Xuzhou Medical University and Huai'an Second People's Hospital, Huai'an, China.

Iscience
|November 6, 2023
PubMed

Insights

Xanthine oxidoreductase (XOR) activity is linked to chronic kidney disease (CKD) biomarkers. This study reveals XOR

Area of Science:

  • Nephrology
  • Biochemistry
  • Genomics

Background:

  • Chronic kidney disease (CKD) poses a significant global health burden.
  • The precise role of xanthine oxidoreductase (XOR) activity in CKD pathogenesis is not well understood.

Purpose of the Study:

  • To investigate the association between XOR activity and CKD.
  • To identify molecular markers and metabolic pathways related to XOR activity in CKD.

Main Methods:

  • Analysis of clinical data and Gene Expression Omnibus (GEO) CKD datasets.
  • Application of bioinformatics algorithms (LASSO, Random Forest) for marker screening.
  • Untargeted metabolomics to explore metabolic pathway enrichment.

Main Results:

  • XOR activity strongly correlated with key CKD biomarkers (serum creatinine, BUN, uric acid, eGFR).
  • Bioinformatic analyses identified differentially expressed genes, validated by qRT-PCR (XDH, KOX-1, ROMO1).
  • Untargeted metabolomics indicated significant enrichment of the purine metabolism pathway in kidney fibrosis models.

Conclusions:

  • XOR activity is a potential indicator and player in CKD progression.
  • Purine metabolism alterations are implicated in CKD pathophysiology.
  • Further research into XOR modulation could offer novel therapeutic strategies for CKD.
Keywords:
Human geneticsMolecular physiologyPathophysiology

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