Primary Malignant Melanoma of the Urethra: A Rare Finding

Primary urinary tract metastatic melanoma is an extremely rare cancer involving the urinary tract. In the majority of melanomas, skin melanocytes can become damaged by ultraviolet radiation and cause melanoma. However, in rare cases, melanocytes in mucosal tissue can develop into melanoma, which can be challenging to diagnose and treat. This case report describes managing and treating a patient with an extremely rare primary cancer finding. We describe the case of a patient who was diagnosed with primary metastatic melanoma of the urinary tract following an extensive and detailed diagnostic period of 2.5 months. After review by an interdisciplinary tumor board and a shared decision-making process with the patient, he agreed to immunotherapy with ipilimumab and nivolumab. The patient survived nearly five months after the initiation of treatment. The cause of death was challenging to determine due to it being unwitnessed; however, it is suspected to be cardiovascular-related, owing to a history of severe cardiovascular disease and an acute stress event prior to death.