Related Experiment Video

Updated: Jul 11, 2025

Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach
07:49

Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach

Published on: July 21, 2023

1.4K

Cardiotrophin-1 in Asymptomatic Hypertensive Patients With Mild Diastolic Dysfunction: Potential Prognostic Value in

Ioannis Vlahodimitris1, Dimos Karangelis2, Maria Moschaki3

  • 1Cardiology, Laiko General Hospital of Athens, Athens, GRC.

Cureus
|November 6, 2023
PubMed

Insights

Cardiotrophin-1 (CT-1) levels are elevated in asymptomatic hypertensive patients with early diastolic dysfunction, suggesting its potential as an early prognostic biomarker for hypertensive heart disease.

Area of Science:

  • Cardiology
  • Biomarkers
  • Hypertension Research

Background:

  • Heart failure (HF) remains a significant cause of mortality and morbidity despite technological advancements.
  • Arterial hypertension is a major risk factor for HF, but the transition from hypertension to HF is not fully understood.
  • Cardiotrophin-1 (CT-1) is a potential prognostic biomarker for HF in hypertensive individuals.

Purpose of the Study:

  • To investigate elevated Cardiotrophin-1 (CT-1) levels in asymptomatic hypertensive patients.
  • To assess the role of CT-1 as an early biomarker in hypertensive heart disease.

Main Methods:

  • Evaluated CT-1 and brain natriuretic peptide (BNP) levels in 40 asymptomatic hypertensive patients with early diastolic dysfunction (grade I) and 20 healthy controls.
  • Assessed various echocardiographic parameters, including E/E' ratio.
  • Analyzed CT-1 levels in relation to left ventricular hypertrophy and diastolic dysfunction severity.

Main Results:

  • Hypertensive patients showed higher CT-1 levels compared to normotensive controls.
  • Elevated CT-1 levels were observed irrespective of left ventricular hypertrophy.
  • Patients with marginal diastolic dysfunction (E/E' > 8 and <14) had significantly higher CT-1 levels (2069 ± 576 pg/ml) than those with normal E/E' < 8 (1165 ± 471 pg/ml), p = 0.001.

Conclusions:

  • Asymptomatic hypertensive patients with mild diastolic dysfunction exhibit elevated CT-1 levels.
  • CT-1 may serve as a valuable prognostic biomarker in the early stages of hypertensive heart disease.
  • Further research is warranted to confirm the prognostic utility of CT-1.
Abstract

Keywords:
bnpcardiotrophin-1diastolic dysfunctionheart failurehypertension

More Related Videos

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix10:21

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Published on: June 14, 2016

10.1K
A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats07:31

A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats

Published on: December 2, 2016

10.1K

Related Concept Videos

Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
15
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
15
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
14
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
11
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
14
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.6K