Related Experiment Video

Updated: Jul 11, 2025

A Porcine Model of Acute Autologous Pulmonary Embolism
07:44

A Porcine Model of Acute Autologous Pulmonary Embolism

Published on: September 6, 2024

422

CXCL10 May Be Responsible for Susceptibility to Pulmonary Embolism in COVID-19 Patients

Yingli Liu1, Dan Si2, Pingping Bai3

  • 1Department of Pulmonary and Critical Care Medicine, Zhengzhou University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, Henan, 450003, People's Republic of China.

Journal of Inflammation Research
|November 6, 2023
PubMed

Insights

Researchers identified 36 common genes between COVID-19 and pulmonary embolism (PE). CXCL10 was found to be a key gene, potentially explaining why COVID-19 patients develop PE.

Area of Science:

  • Genomics
  • Immunology
  • Pathogenesis

Background:

  • Pulmonary embolism (PE) is a known complication of coronavirus disease 2019 (COVID-19), but the underlying mechanisms remain unclear.
  • Identifying shared genetic factors could elucidate the pathogenesis of PE susceptibility in COVID-19 patients.

Purpose of the Study:

  • To identify genes common to both COVID-19 and PE.
  • To understand the molecular mechanisms contributing to PE development in COVID-19.

Main Methods:

  • Gene expression data for COVID-19 and PE were collected from public databases.
  • Common genes were identified through overlap analysis.
  • Functional enrichment, protein-protein interaction, and immune infiltration analyses were performed.
  • Hub genes were identified and validated in independent datasets and clinical samples.

Main Results:

  • Thirty-six genes were found to be common to both COVID-19 and PE.
  • Functional analyses indicated the involvement of cytokines and immune activation.
  • Five hub genes were identified, including CCL2, CXCL10, ALB, EGF, and MKI67.
  • CXCL10 was validated and showed significantly elevated serum levels in COVID-19 patients with and without PE compared to healthy controls.

Conclusions:

  • This study identified shared genes between COVID-19 and PE, highlighting potential pathogenic pathways.
  • CXCL10 is proposed as a key factor contributing to PE susceptibility in COVID-19 patients.
Abstract

Keywords:
CXCL10bioinformaticscoronavirus disease 2019pulmonary embolism

More Related Videos

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma10:21

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

470
Visualizing Lung Cellular Adaptations during Combined Ozone and LPS Induced Murine Acute Lung Injury14:48

Visualizing Lung Cellular Adaptations during Combined Ozone and LPS Induced Murine Acute Lung Injury

Published on: March 21, 2021

5.1K

Related Concept Videos

Pulmonary Embolism I: Introduction01:29

Pulmonary Embolism I: Introduction

Pulmonary embolism (PE) occurs when a thrombus, fat or air embolus, amniotic fluid, or tumor tissue blocks one or more pulmonary arteries. These blockages originate in the venous system or the right side of the heart.EtiologyPE primarily arises from deep vein thrombosis (DVT) and other hypercoagulable states, such as inherited thrombophilias. Additional etiological factors include venous stasis, commonly seen in obesity, and endothelial injury from surgery and trauma. Less common causes include...
7
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care01:29

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
10
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
2.8K
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
302
Chronic Obstructive Pulmonary Disease01:22

Chronic Obstructive Pulmonary Disease

COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
1.3K