Related Experiment Video
Updated: Jul 11, 2025
28:13
Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
Published on: February 26, 2013
33.4K
Inflammation and Coagulation are Two Interconnected Pathophysiological Pathways in Atrial Fibrillation Pathogenesis
Lusine Hazarapetyan1,2, Parounak H Zelveian2, Svetlana Grigoryan1,2
1Department of Cardiology, Yerevan State Medical University Named After M. Heratsi, Yerevan, Armenia.
Journal of Inflammation Research
|November 6, 2023
Summary
Atrial fibrillation (AF) patients show higher inflammation and clotting factors. These markers correlate with structural heart changes, indicating a link between inflammation, coagulation, and atrial remodeling in AF.
Area of Science:
- Cardiology
- Biochemistry
- Pathophysiology
Background:
- Atrial fibrillation (AF) is linked to increased clotting factors like tissue factor (TF) and factor XII (FXII).
- Elevated inflammation markers, including interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and high-sensitive C-reactive protein (hs-CRP), are also associated with AF.
Purpose of the Study:
- To investigate the relationship between inflammation markers and coagulation activity in patients with nonvalvular AF.
- To explore the impact of these markers on structural heart changes, specifically atrial remodeling.
Main Methods:
- Studied 283 patients with nonvalvular AF and a control group.
- Measured coagulation and inflammation markers using ELISA.
- Analyzed data using SPSS statistical software.
Main Results:
- AF patients exhibited significantly higher levels of hs-CRP, IL-6, TNF-α, TF, and FXII compared to controls.
- Moderate correlations were found between IL-6 and left atrial diameter/stiffness, and between hs-CRP/TF and left atrial volume.
Conclusions:
- Patients with AF demonstrate a relationship between elevated inflammatory markers and coagulation activity.
- This interplay contributes to structural atrial remodeling in AF patients.
More Related Videos
Related Concept Videos
01:20Extrinsic and Intrinsic Pathways of Hemostasis
8.0K
Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
8.0K
01:30Anticoagulant Drugs: Low-Molecular-Weight Heparins
719
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
719
01:16Clot Retraction and Fibrinolysis
6.2K
After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
6.2K
01:09Coagulation
6.9K
The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
6.9K
01:30Venous Thrombosis I: Introduction
11
Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
11
01:05Introduction to Hemostasis
8.1K
Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
8.1K