The pathogenesis of post-stroke osteoporosis and the role oxidative stress plays in its development

Area of Science:

• Gerontology
• Cardiology
• Orthopedics

Background:

• Cardiovascular disease and osteoporotic fractures (OF) are leading health concerns for middle-aged and elderly individuals.
• Global population aging is increasing the incidence and prevalence of both conditions.
• The interplay between cardiovascular disease and OF risk/prognosis is a growing area of research.

Purpose of the Study:

• To review the relationship between stroke, its treatments, and the risk of OF.
• To explore the role of oxidative stress in the shared pathophysiology.
• To provide a basis for identifying high-risk fracture groups and informing interventions.

Main Methods:

• Systematic review of recent domestic and international literature.
• Analysis of the association between stroke and osteoporotic fractures.
• Examination of the pathophysiological mechanisms, including oxidative stress.

Main Results:

• Stroke and associated medications may influence the risk and outcomes of osteoporotic fractures.
• Oxidative stress is implicated as a key factor in the pathogenesis linking these conditions.
• Evidence suggests a significant association requiring further investigation for clinical application.

Conclusions:

• A comprehensive understanding of the stroke-OF link is crucial for managing aging populations.
• Targeted interventions based on shared risk factors, like oxidative stress, are needed.
• This review provides a foundation for screening high-risk individuals and reducing healthcare burdens.