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Updated: Jul 11, 2025
09:31
Visualization of Gut Microbiota-host Interactions via Fluorescence In Situ Hybridization, Lectin Staining, and Imaging
Published on: July 9, 2021
8.3K
Colorectal cancer and gut viruses: a visualized analysis based on CiteSpace knowledge graph
Chu Jian1,2,3, Zhuang Jing1,2,3, Wu Yinhang1,2,3
1Fifth School of Clinical Medicine of Zhejiang Chinese Medical University (Huzhou Central Hospital), Huzhou, China.
Frontiers in Microbiology
|November 6, 2023
Summary
This study analyzed 356 articles on colorectal cancer (CRC) and viruses, revealing human cytomegalovirus (CMV) as a key research area. Emerging frontiers include oncolytic viruses and gut microbiome research for CRC.
Area of Science:
- Oncology
- Virology
- Microbiology
Background:
- The gut microbiome significantly influences colorectal cancer (CRC) development and progression.
- The intricate relationship between viruses and CRC remains incompletely understood.
- Identifying research trends is crucial for advancing CRC and virology studies.
Purpose of the Study:
- To map the research landscape of colorectal cancer (CRC) and viruses.
- To identify key research hotspots and emerging trends in this field.
- To provide insights for future research directions in CRC and viral oncology.
Main Methods:
- Bibliometric analysis of 356 articles from the Web of Science Core Collection (2001-2023).
- Utilized CiteSpace software for visual analysis of countries, institutions, and keywords.
- Analyzed publication trends, collaborations, and keyword clusters.
Main Results:
- The USA and China are leading contributors in CRC and virus research.
- The Helmholtz Association published the most papers in this domain.
- Human cytomegalovirus (CMV) and CRC is the most studied topic, with "gut microbiota," "inflammatory bowel disease," "hepatitis B virus," and "human papillomavirus infection" as current hotspots.
- "Oncolytic virus," "apoptosis," and "gut microbiome" represent emerging research frontiers.
Conclusions:
- Bibliometric analysis using CiteSpace effectively visualizes research trends and hot topics in CRC and virus research.
- Understanding the prevalence and mechanisms of specific viruses in CRC offers valuable insights.
- This review provides a foundation for future investigations into viral roles in colorectal cancer.
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