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Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model
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Pathophysiology of spontaneous coronary artery dissection: hematoma, not thrombus

Aleksandra Djokovic1,2, Gordana Krljanac1,3, Predrag Matic1,4

  • 1Faculty of Medicine, University of Belgrade, Belgrade, Serbia.

Frontiers in Cardiovascular Medicine
|November 6, 2023
PubMed

Insights

Spontaneous coronary artery dissection (SCAD) affects 1.7%-4% of acute coronary syndrome cases, especially young women. This review covers SCAD

Area of Science:

  • Cardiology
  • Vascular Biology
  • Medical Reviews

Background:

  • Spontaneous coronary artery dissection (SCAD) represents a significant cause of acute coronary syndrome (ACS), particularly in younger women.
  • SCAD accounts for 1.7%-4% of ACS cases, highlighting its clinical relevance.
  • Distinguishing SCAD from atherothrombotic coronary disease and determining optimal treatment remain challenging.

Purpose of the Study:

  • To consolidate current understanding of SCAD pathophysiology.
  • To explore potential therapeutic strategies for SCAD.
  • To provide a contemporary review of SCAD knowledge.

Main Methods:

  • Literature review of recent studies on SCAD.
  • Analysis of known arteriopathies and triggers associated with SCAD.
  • Synthesis of information on diagnostic and therapeutic approaches.

Main Results:

  • SCAD has diverse underlying causes and triggers, with variable prevalence.
  • The etiology of SCAD often remains unidentified.
  • Current therapeutic approaches for SCAD are still evolving.

Conclusions:

  • Further research is needed to fully elucidate SCAD pathophysiology.
  • Developing standardized diagnostic and therapeutic guidelines for SCAD is crucial.
  • Increased awareness and understanding of SCAD are essential for improved patient outcomes.

Keywords:
acute coronary syndromefibromuscular dysplasiapathophysiologypregnancyspontaneous coronary artery dissectionwomen’s health

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