Related Experiment Video

Updated: Jul 11, 2025

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

609

Hepatitis Status and its Effect upon the Progression of Chronic Kidney Disease: Presentations, Associations and

Shamsa AlMaawali1, Issa Al Salmi2, Ahmed Al-Darmaki3

  • 1Department of Medicine, Royal Hospital, Muscat, Oman.

Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia
|November 6, 2023
PubMed

Insights

Chronic kidney disease (CKD) is significantly associated with viral hepatitis (hepatitis B virus and hepatitis C virus) in Oman. Hepatitis C virus infection showed the highest CKD prevalence, emphasizing the need for kidney function monitoring.

Area of Science:

  • Nephrology
  • Hepatology
  • Epidemiology

Background:

  • Chronic kidney disease (CKD), hepatitis B virus (HBV), and hepatitis C virus (HCV) are prevalent in Oman.
  • A significant association between viral hepatitis and CKD risk has been suggested.

Purpose of the Study:

  • To investigate the association between CKD and viral hepatitis (HBV and HCV) in Oman.
  • To evaluate the prevalence of CKD in patients with chronic HBV, chronic HCV, and HBV/HCV coinfection.

Main Methods:

  • An observational cohort study was conducted at the Royal Hospital, Sultanate of Oman.
  • 233 patients were analyzed: 112 with chronic HBV, 112 with chronic HCV, and 9 with coinfection.
  • Prevalence of CKD and mean estimated glomerular filtration rate (eGFR) were calculated for each group.

Main Results:

  • CKD prevalence was 51% in HBV, 78% in HCV, and 56% in coinfection groups.
  • Mean eGFR was lowest in the coinfection group (57.6 mL/min/1.73 m²).
  • HCV infection showed the highest CKD prevalence and the fastest decline in renal function.

Conclusions:

  • Viral hepatitis, particularly HCV infection and coinfection, is significantly and independently associated with an increased risk of CKD.
  • Close monitoring of kidney function is crucial for patients with viral hepatitis.
  • Screening for viral hepatitis is recommended for patients diagnosed with CKD.

More Related Videos

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma12:24

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

Published on: September 30, 2021

5.2K
Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform07:13

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Published on: April 12, 2021

4.3K

Related Concept Videos

Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage kidney disease (ESKD). At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate...
17
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
13
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
11
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
11
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
18
Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
9