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Published on: March 19, 2020
Biological and computational investigation of transition metal(II) complexes of 2-phenoxyaniline-based ligands
Binesh Kumar1, Jai Devi1, Amit Dubey2,3
1Department of Chemistry, Guru Jambheshwar University of Science & Technology, Hisar, Haryana, 125001, India.
Abstract:
Aim: In the 21st century, we are witness of continuous onslaughts of various pathogen deformities which are a major cause of morbidity and mortality worldwide. Therefore, to investigate the grave for these deformities, antioxidant, anti-inflammatory and antimicrobial biological activities were carried out against newly synthesized Schiff base ligands and their transition metal complexes, which are based on newly synthesized 2-phenoxyaniline and salicylaldehyde derivatives. Materials & methods: The synthesized compounds were characterized by various physiochemical studies, demonstrating the octahedral stereochemistry of the complexes. Results: The biological assessments revealed that complex 6 (3.01 ± 0.01 μM) was found to be highly active for oxidant ailments whereas complex 14 (7.14 ± 0.05 μM, 0.0041-0.0082 μmol/ml) was observed as highly potent for inflammation and microbial diseases. Conclusion: Overall, the biological and computational studies demonstrate that the nickel(II) complex 14 can act as an excellent candidate for pathogen deformities.
Insights
Newly synthesized Schiff base ligands and their metal complexes show significant antioxidant, anti-inflammatory, and antimicrobial activities. Nickel(II) complex 14 demonstrates potent efficacy against pathogen-related deformities, offering a promising therapeutic candidate.
Area of Science:
- Medicinal Chemistry
- Inorganic Chemistry
- Biochemistry
Background:
- Pathogen-induced diseases pose a significant global health challenge, causing widespread morbidity and mortality.
- Developing novel therapeutic agents with broad biological activities is crucial for combating emerging infectious diseases.
Purpose of the Study:
- To synthesize novel Schiff base ligands and their transition metal complexes.
- To evaluate the antioxidant, anti-inflammatory, and antimicrobial properties of these compounds.
- To identify potent candidates for treating pathogen-related deformities.
Main Methods:
- Synthesis and characterization of Schiff base ligands and metal complexes using physiochemical methods.
- Assessment of biological activities including antioxidant, anti-inflammatory, and antimicrobial assays.
- Computational studies to support biological findings.
Main Results:
- Complex 6 exhibited high activity against oxidant ailments (3.01 ± 0.01 μM).
- Complex 14 demonstrated potent anti-inflammatory and antimicrobial effects (7.14 ± 0.05 μM, 0.0041-0.0082 μmol/ml).
- Octahedral stereochemistry was confirmed for the metal complexes.
Conclusions:
- Nickel(II) complex 14 shows significant potential as a therapeutic agent for pathogen deformities.
- The synthesized compounds, particularly complex 14, offer promising leads for drug development.
- Combined biological and computational data support the efficacy of complex 14.
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