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Low utilization of statins in patients with dermatomyositis/polymyositis and hyperlipidemia: a multicenter USA-based

Joseph Fares1, Ross Summer1, Giorgos Loizidis2

  • 1Division of Pulmonary and Critical Care, Department of Medicine, The Jane and Leonard Korman Respiratory Institute, Thomas Jefferson University, Philadelphia, PA, USA.

Clinical Rheumatology
|November 6, 2023
PubMed

Insights

Statin prescription is lower for dermatomyositis/polymyositis-hyperlipidemia patients than rheumatoid arthritis-hyperlipidemia patients. However, statin use in DM/PM-HLD patients significantly reduces mortality risk.

Area of Science:

  • Rheumatology
  • Cardiology
  • Pharmacology

Background:

  • Statins are proven cardioprotective for rheumatoid arthritis (RA) patients.
  • Hesitancy exists in prescribing statins for dermatomyositis/polymyositis (DM/PM) patients with hyperlipidemia (HLD), especially those with myopathy.
  • Understanding statin use patterns and outcomes in DM/PM-HLD is crucial.

Purpose of the Study:

  • To compare statin prescription rates between DM/PM-HLD and RA-HLD patients.
  • To investigate mortality differences between DM/PM-HLD patients who use statins and those who do not.
  • To highlight potential disparities in cardiovascular care for inflammatory myopathies.

Main Methods:

  • Analysis of anonymized US health data from the TriNetX database over 10 years.
  • Inclusion criteria: diagnosis of HLD after initial diagnosis of DM/PM or RA.
  • Propensity score matching was used to adjust for demographic and cardiovascular risk factors.

Main Results:

  • The study included 33,000 RA-HLD patients and 1,079 DM/PM-HLD patients.
  • Statin initiation was significantly lower in DM/PM-HLD patients (17.91%) compared to RA-HLD patients (27.4%).
  • DM/PM-HLD patients using statins had a significantly lower mortality rate (75 deaths/1000/year) versus non-users (147 deaths/1000/year).

Conclusions:

  • A significant disparity exists in statin initiation between DM/PM-HLD and RA-HLD patients.
  • DM/PM-HLD patients not using statins experienced higher mortality rates.
  • Further research is needed to address this discrepancy and develop tailored cardiovascular guidelines for DM/PM-HLD patients.
Abstract

Keywords:
DermatomyositisHMG Co-A reductaseHyperlipidemiaMortalityRheumatoid arthritisStatin

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