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Impact of percutaneous coronary intervention on renal function in patients with coronary heart disease

Bing Ji1, Tongqing Yao1, Jing Tong1

  • 1Department of Cardiology, Tongji Hospital, School of Medicine, Tongji University, Shanghai.

Monaldi Archives for Chest Disease = Archivio Monaldi Per Le Malattie Del Torace
|November 6, 2023
PubMed

Insights

Percutaneous coronary intervention (PCI) generally maintains renal function in most patients with coronary artery disease. Improved renal function (IRF) post-PCI is linked to better outcomes and reduced major adverse cardiovascular events (MACE).

Area of Science:

  • Cardiology
  • Nephrology
  • Interventional Cardiology

Background:

  • The interplay between cardiac and renal function is complex.
  • The effect of percutaneous coronary intervention (PCI) on renal function in patients with coronary artery disease remains incompletely understood.

Purpose of the Study:

  • To evaluate changes in renal function, including its temporal course, after elective PCI.
  • To identify predictors of major adverse cardiovascular events (MACE) related to renal function.
  • To assess improved renal function (IRF) post-PCI.

Main Methods:

  • Retrospective cohort study of 1572 coronary heart disease patients undergoing coronary angiography (CAG) or PCI (2013-2018).
  • Analysis of pre-PCI and procedural variables impacting post-PCI estimated glomerular filtration rate (eGFR).
  • Investigation of the association between post-PCI eGFR and MACE.

Main Results:

  • 88.7% of patients in the PCI group maintained unchanged improved renal function (IRF) post-procedure.
  • PCI treatment was an independent predictor of IRF post-CAG (odds ratio 4.561, p<0.001).
  • Both IRF and stable renal function correlated with a reduced risk of MACE.

Conclusions:

  • Elective PCI is associated with stable or improved renal function in the majority of coronary heart disease patients.
  • Maintaining renal function post-PCI is a favorable prognostic indicator for cardiovascular outcomes.
  • PCI treatment itself is a significant factor in achieving improved renal function.

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