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Related Experiment Video

Updated: Jul 11, 2025

Generation of Human 3D Lung Tissue Cultures 3D-LTCs for Disease Modeling
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Bioprinted Human Lung Cancer-Mimics for Tissue Diagnostics Applications.

Mian Wang1, Wanlu Li1, Regina Sanchez Flores1

  • 1Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, Massachusetts, USA.

Tissue Engineering. Part A
|November 6, 2023
PubMed
Summary
This summary is machine-generated.

Researchers developed 3D bioprinting to create standardized, customizable tissue mimics for diagnostic assays. This overcomes limitations of patient-derived tissues, offering a sustainable solution for advancing medical diagnostics and 3D bioprinting applications.

Keywords:
biofabricationbioinkbioprintinglung cancerporoustissue model

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Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Cancer Diagnostics

Background:

  • Standardized control tissues are crucial for diagnostic, prognostic, and predictive assays.
  • Patient-derived tissues present challenges: variable composition, unknown preanalytics, limited supply, and high costs.
  • Current methods lack reproducibility and customization for specific diagnostic needs.

Purpose of the Study:

  • To develop a reproducible and sustainable method for producing customizable control tissues for diagnostics.
  • To leverage 3D bioprinting technology to create native-like tissue mimics.
  • To address the limitations associated with conventional patient-derived control tissues.

Main Methods:

  • Utilized three-dimensional (3D) bioprinting technology with digital light processing.
  • Developed a micropore-forming bioink incorporating tumor cells (anaplastic lymphoma kinase-positive lung cancer).
  • Fabricated structural and functional tissue mimics resembling native lung cancer tissues.

Main Results:

  • Successfully produced stable, native-like anaplastic lymphoma kinase-positive lung cancer tissue mimics.
  • Demonstrated the potential for structural and functional relevancy in diagnostic applications.
  • Showcased a reproducible strategy for generating customizable tissue-mimics.

Conclusions:

  • 3D bioprinting offers a viable strategy for producing standardized and customizable control tissues.
  • This methodology enhances the scope and sustainability of tissue diagnostics and 3D bioprinting.
  • The developed tissue mimics hold promise for improving patient care through advanced diagnostic assays.