Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

TIPs: a deep learning-guided proteogenomic framework to expand the landscape of transposable element-derived antigens with immunopeptidomics.

Genome biology·2026
Same author

Tuning the size and defect chemistry of TiO<sub>2</sub><i>via</i> flash nanoprecipitation for enhanced photocatalytic antibacterial activity.

Nanoscale·2026
Same author

Biological aging and the incidence and progression of diabetic retinopathy and kidney disease in type 2 diabetes mellitus: A prospective cohort study.

Diabetes research and clinical practice·2026
Same author

Safety and early efficacy of iPSC-derived motor neuron progenitor cells in subacute spinal cord injury: protocol for a phase I, multicentre, open-label, single-arm trial.

BMJ open·2026
Same author

Core gastric microbiota linked to pathogenesis and preserved across age-stratified cohorts.

Cell reports. Medicine·2026
Same author

Selecting suitable entities to implement blockchain in green agricultural supply chains.

PloS one·2026

Related Experiment Video

Updated: Jul 11, 2025

Cortical Actin Flow in T Cells Quantified by Spatio-temporal Image Correlation Spectroscopy of Structured Illumination Microscopy Data
09:09

Cortical Actin Flow in T Cells Quantified by Spatio-temporal Image Correlation Spectroscopy of Structured Illumination Microscopy Data

Published on: December 17, 2015

9.8K

SCAN: Spatiotemporal Cloud Atlas for Neural cells.

Yushan Deng1, Yubao Lu2, Mengrou Li1,3

  • 1State Key Laboratory of Common Mechanism Research for Major Diseases, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou 215123, China.

Nucleic Acids Research
|November 6, 2023
PubMed
Summary

Scientists developed SCAN, a database integrating spatial transcriptomics and scRNA-seq data for neural cells. This tool aids in understanding nervous system complexity and identifying biomarkers for neurological diseases.

More Related Videos

Author Spotlight: Deciphering Neural Circuit Formation from Two-Photon Microscopy and Single Neuron Imaging
06:18

Author Spotlight: Deciphering Neural Circuit Formation from Two-Photon Microscopy and Single Neuron Imaging

Published on: November 21, 2023

826
Time-Lapse Imaging of Neuronal Arborization using Sparse Adeno-Associated Virus Labeling of Genetically Targeted Retinal Cell Populations
13:13

Time-Lapse Imaging of Neuronal Arborization using Sparse Adeno-Associated Virus Labeling of Genetically Targeted Retinal Cell Populations

Published on: March 19, 2021

2.9K

Related Experiment Videos

Last Updated: Jul 11, 2025

Cortical Actin Flow in T Cells Quantified by Spatio-temporal Image Correlation Spectroscopy of Structured Illumination Microscopy Data
09:09

Cortical Actin Flow in T Cells Quantified by Spatio-temporal Image Correlation Spectroscopy of Structured Illumination Microscopy Data

Published on: December 17, 2015

9.8K
Author Spotlight: Deciphering Neural Circuit Formation from Two-Photon Microscopy and Single Neuron Imaging
06:18

Author Spotlight: Deciphering Neural Circuit Formation from Two-Photon Microscopy and Single Neuron Imaging

Published on: November 21, 2023

826
Time-Lapse Imaging of Neuronal Arborization using Sparse Adeno-Associated Virus Labeling of Genetically Targeted Retinal Cell Populations
13:13

Time-Lapse Imaging of Neuronal Arborization using Sparse Adeno-Associated Virus Labeling of Genetically Targeted Retinal Cell Populations

Published on: March 19, 2021

2.9K

Area of Science:

  • Neuroscience
  • Genomics
  • Bioinformatics

Background:

  • The nervous system's complexity necessitates advanced tools for cellular and spatial analysis.
  • Spatial transcriptomics (ST) and single-cell RNA sequencing (scRNA-seq) offer powerful methods for neural system research.
  • Integrating and analyzing large multiomic datasets presents a significant challenge.

Purpose of the Study:

  • To create a comprehensive database for exploring neural cell heterogeneity and spatial organization.
  • To facilitate data mining of multiomic datasets from an evolutionary perspective.
  • To enable high-throughput screening of potential biomarkers for over 100 neurological diseases.

Main Methods:

  • Manual collection and analysis of high-quality scRNA-seq and ST data from the nervous system (over 10 million cells).
  • Inclusion of multiomic datasets from over 900 species for evolutionary analysis.
  • Systematic analysis of data from over 100 neurological diseases.

Main Results:

  • Identification of differential expression patterns across developmental stages, cell types, and ST spots.
  • Creation of the Spatiotemporal Cloud Atlas for Neural cells (SCAN) database.
  • SCAN provides interactive interfaces for efficient data exploration and analysis.

Conclusions:

  • SCAN offers a valuable resource for the neuroscience community to explore the neural system's spatiotemporal atlas.
  • The database facilitates the discovery of novel insights into neural development and function.
  • SCAN supports the development of diagnostic strategies for neurological disorders.