Related Experiment Video
Updated: Jul 11, 2025
08:49
Murine Ileocolic Bowel Resection with Primary Anastomosis
Published on: October 29, 2014
16.5K
Rates of Endoscopic Recurrence In Postoperative Crohn's Disease Based on Anastomotic Techniques: A Systematic Review
Olga Maria Nardone1,2, Giulio Calabrese3, Brigida Barberio4
1Gastroenterology, Department of Public Health, School of Medicine, Federico II University of Naples, Naples, Italy.
Inflammatory Bowel Diseases
|November 6, 2023
Summary
The Kono-S anastomosis technique significantly reduces endoscopic postoperative recurrence in Crohn's disease patients after ileocolic resection compared to conventional methods. This finding suggests Kono-S may be a preferred surgical approach for managing Crohn's disease recurrence.
Area of Science:
- Gastroenterology
- Surgical Oncology
- Inflammatory Bowel Disease Research
Background:
- Crohn's disease (CD) patients undergoing ileocolic resection face high rates of endoscopic postoperative recurrence (ePOR), ranging from 40-70% within six months.
- Anastomotic configuration is increasingly recognized as a factor influencing ePOR.
- The Kono-S anastomosis has emerged as a potential strategy to mitigate ePOR risk, yet comparative data across multiple anastomosis types remain limited.
Approach:
- A systematic review and meta-analysis was conducted, searching PubMed and Embase up to January 2023.
- Studies were categorized by anastomosis type: conventional (side-to-side, end-to-end, end-to-side) versus Kono-S.
- Pooled incidence rates of ePOR at six months or later were calculated using random-effect modeling.
Key Points:
- Seventeen studies involving 2087 CD patients were analyzed.
- The overall pooled incidence of ePOR was 37.2%.
- Patients with Kono-S anastomosis exhibited a lower ePOR incidence (24.7%) compared to those with conventional anastomosis (42.6%).
Conclusions:
- Kono-S ileocolic anastomosis demonstrates a reduced likelihood of ePOR at six months or more post-surgery compared to conventional techniques.
- Implementing Kono-S anastomosis may be beneficial, especially for challenging CD cases.
- Further validation through large-scale randomized controlled trials is recommended to confirm these findings.
Related Concept Videos
01:21Inflammatory Bowel Disease V: Surgical Management
149
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Here are some common surgical interventions for IBD:
149
01:26Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy
95
Sigmoidoscopy and laparoscopy are distinct medical procedures that enable physicians to internally inspect different parts of the GI tract. Although they serve different purposes, each is essential for diagnosing and, in some cases, treating various medical conditions.
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
95