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Aromatase enzyme: Paving the way for exploring aromatization for cardio-renal protection

Manar A Eissa1, Eman Y Gohar2

  • 1Department of Pharmacology and Toxicology, Faculty of Pharmacy, Merit University, New Sohag, Sohag, Egypt.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|November 6, 2023
PubMed

Insights

Aromatase, the enzyme converting androgens to estrogens, may offer cardio-renal protection. Inhibiting this enzyme is linked to cardiovascular events, suggesting its protective role.

Area of Science:

  • Endocrinology
  • Cardiovascular Science
  • Nephrology

Background:

  • Estrogens mediate cardio-renal protection via estrogen receptors (ERα, ERβ) and G protein-coupled estrogen receptor, interacting with the renin-angiotensin-aldosterone system.
  • Aromatase (estrogen synthase) is crucial for androgen-to-estrogen conversion in gonadal and extra-gonadal sites.

Approach:

  • Review of scientific literature on aromatase function.
  • Analysis of meta-analysis studies on cardiovascular events linked to aromatase inhibitors.
  • Examination of the role of aromatization in cardio-renal protection.

Key Points:

  • Aromatase inhibitors, used for estrogen-related pathologies, are associated with increased cardiovascular events.
  • Estrogen's protective effects on cardiovascular and renal systems are well-documented.
  • Aromatization is a key process in estrogen biosynthesis.

Conclusions:

  • Aromatase plays a fundamental role in cardio-renal protection.
  • Further research into aromatase's mechanisms could reveal novel therapeutic targets.
  • Understanding aromatase function is critical for managing cardiovascular and chronic kidney diseases.
Keywords:
Aromatase inhibitorsCardiovascularEstrogen synthaseKidneyMeta-analysis

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