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Related Experiment Videos

Variable susceptibility to immune complex glomerulonephritis among mice sharing the same major histocompatibility

K R McLeish, G T Stelzer, A F Gohara

    Immunological Investigations
    |October 1, 1986
    PubMed
    Summary

    Susceptibility to immune complex glomerulonephritis (ICGN) in mice depends on antibody response levels, not just MHC haplotype. High antibody production against horse apoferritin (HAF) correlated with ICGN development.

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    Medical College of Ohio.

    Academic medicine : journal of the Association of American Medical Colleges·2000

    Area of Science:

    • Immunology
    • Nephrology
    • Genetics

    Background:

    • Immune complex glomerulonephritis (ICGN) is a kidney disease.
    • The major histocompatibility complex (MHC) influences immune responses.
    • Genetic factors play a role in ICGN susceptibility.

    Purpose of the Study:

    • To investigate the role of MHC haplotype and antibody response magnitude in ICGN induction.
    • To determine if different mouse strains with the same MHC haplotype exhibit varying ICGN susceptibility.

    Main Methods:

    • Three inbred mouse strains (B10.BR, CBA, C3H/HeJ) sharing the H-2k MHC haplotype were used.
    • Mice were injected with horse apoferritin (HAF) using two different dose schedules over 4 weeks.
    • Glomerular morphology, immunoglobulin deposition, and serum anti-HAF antibody levels were assessed.

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    Main Results:

    • All three mouse strains showed varying susceptibilities to ICGN.
    • ICGN and glomerular immunoglobulin deposition occurred only in mice with high antibody responses to HAF.
    • This occurred irrespective of the HAF dose schedule used.

    Conclusions:

    • Susceptibility to ICGN in this model is linked to antigen exposure levels and antibody response magnitude.
    • The major histocompatibility complex (MHC) does not strictly control ICGN susceptibility in this context.
    • Individual mouse strain responses highlight the complexity of autoimmune disease development.