Related Experiment Video
Updated: Jul 11, 2025

Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells
Published on: January 18, 2017
Identifying and reducing inappropriate aspirin use in primary care.
Christa Brooker1, Rebekah Compton1, Terri Babineau1
1Department of Family Medicine, University of Virginia, Charlottesville, Virginia, USA.
A quality improvement intervention identified older adults taking aspirin for primary prevention. Education and provider review led to aspirin de-prescribing in 29% of patients, improving medication safety.
Area of Science:
- Geriatric Medicine
- Cardiovascular Disease Prevention
- Pharmacology
Background:
- Recent evidence questions aspirin's safety for primary prevention of atherosclerotic cardiovascular disease (ASCVD) in older adults.
- Identifying and managing inappropriate aspirin use in this demographic is crucial.
Purpose of the Study:
- To develop a systematic approach for identifying patients aged 70+ on aspirin for primary prevention.
- To educate patients and providers on updated aspirin safety guidelines.
- To evaluate the impact of this intervention on aspirin de-prescribing.
Main Methods:
- Quality improvement intervention in two family medicine practices.
- Electronic medical record-based chart review to determine aspirin indication.
- Shared decision-making and patient/provider education.
- Longitudinal follow-up to assess de-prescribing rates.
Main Results:
- 145 of 361 (40%) patients aged 70+ were taking aspirin for primary ASCVD prevention.
- Aspirin was de-prescribed in 42 (29%) patients after 9 months.
- Patients seen by providers had significantly lower odds of remaining on aspirin (OR=0.87).
Conclusions:
- This study presents a novel, EMR-based method to identify and reduce inappropriate aspirin use in older adults.
- The intervention successfully facilitated aspirin de-prescribing, enhancing medication safety.
- This approach can be scaled to larger populations to optimize primary prevention strategies.
Related Concept Videos
Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
Peptic Ulcer Disease IV: Management
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
Prescription, Nonprescription and Orphan Drugs
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
Coronary Artery Disease V: Interprofessional Care
Acute Coronary Syndrome IV: Interprofessional Care
Peripheral Artery Disease III: Interprofessional Care

