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Phantom study investigating the repeatability of radiomic features with alteration of image acquisition parameters in
Rosalind Mitchell-Hay1, Trevor Ahearn2, Alison Murray3
1Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen, Scotland; Radiology Department, NHS Grampian, Aberdeen, Scotland.
Background:
Magnetic resonance imaging (MRI) has many different alterable parameters that affect how an image appears. This is relevant in radiomics which produces quantitative features through analysis of medical images. One significant acknowledged limitation of radiomics is repeatability. This phantom study aims to further investigate the repeatability of radiomic features (RaF), within MRI, across a range of different echo (TE) and repetition times (TR).
Methods:
A phantom was scanned 10 times under identical conditions on a 3T scanner using head coil over 4 months. The TE ranged from 80 to 110 ms while the TR from 3000 to 5000 ms. Radiomics analysis was performed on the same segmented section of the phantom across all TE and TR combinations. Intraclass Correlation Coefficient (ICC) was calculated across the different TE and TR ranges to investigate the repeatability of RaF.
Results:
Of 1596 features calculated, 187 features had ICC >0.9 across the range of TE, while 82 features had an ICC >0.9 across a range of TR. 664 had ICC >0.75 across the range of TEs, with 541 across the range of TR values. There was an overlap of 51 features with ICC >0.9.
Conclusion:
Repeatability of RaF in MRI is dependent on imaging parameters and careful consideration of these, in combination with variable selection, is required when applying radiomics to MRI.
Insights
Repeatability of radiomic features in MRI depends on imaging parameters. Careful selection of echo (TE) and repetition times (TR) is crucial for reliable radiomics analysis.
Area of Science:
- Medical Imaging
- Radiomics
- Quantitative Imaging
Background:
- Magnetic Resonance Imaging (MRI) parameters influence image appearance.
- Radiomics extracts quantitative features from medical images.
- Repeatability is a key limitation in radiomics.
Purpose of the Study:
- Investigate the repeatability of radiomic features (RaF) in MRI.
- Assess the impact of varying echo times (TE) and repetition times (TR) on RaF repeatability.
Main Methods:
- A phantom was scanned 10 times under identical conditions on a 3T MRI scanner.
- Scans were performed across a range of echo times (80-110 ms) and repetition times (3000-5000 ms).
- Radiomic analysis was conducted on segmented phantom sections, with Intraclass Correlation Coefficient (ICC) used to assess repeatability.
Main Results:
- 187 features showed high repeatability (ICC >0.9) across echo time variations.
- 82 features demonstrated high repeatability (ICC >0.9) across repetition time variations.
- Significant overlap (51 features) with ICC >0.9 was observed between TE and TR ranges.
Conclusions:
- The repeatability of radiomic features in MRI is significantly influenced by imaging parameters.
- Careful consideration of echo and repetition times is essential for robust radiomics analysis.
- Variable selection strategies must account for parameter dependencies in MRI radiomics.
