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STIM1 in tumor cell death: angel or devil?
Ran Ren1, Yongsheng Li2,3
1Chongqing University Cancer Hospital, School of Medicine, Chongqing University, 400044, Chongqing, China.
Cell Death Discovery
|November 6, 2023
Summary
Stromal interaction molecule 1 (STIM1) regulates calcium (Ca2+) signaling, impacting tumor cell death and immune responses. Targeting STIM1 offers potential for novel antitumor therapies by modulating these critical cancer processes.
Area of Science:
- Molecular Biology
- Cell Biology
- Cancer Research
Background:
- Stromal interaction molecule 1 (STIM1) is crucial for store-operated calcium (Ca2+) entry (SOCE).
- STIM1 influences key cancer processes including proliferation, metastasis, apoptosis, autophagy, metabolism, and immune responses.
- STIM1 is regulated transcriptionally, post-transcriptionally by miRNAs, and via ubiquitination.
Purpose of the Study:
- To review the structure, function, and regulation of STIM1.
- To summarize STIM1-mediated signaling pathways in tumor cell death.
- To explore STIM1 as a therapeutic target for antitumor strategies.
Main Methods:
- Literature review of STIM1's role in cancer.
- Analysis of STIM1's involvement in various cell death pathways (apoptosis, pyroptosis, ferroptosis).
- Examination of STIM1's influence on the tumor microenvironment and therapy resistance.
Main Results:
- STIM1 and Ca2+ signaling differentially regulate tumor cell death across various cancers.
- STIM1 contributes to resistance against antitumor therapies by affecting tumor cell death mechanisms.
- STIM1 modulates immune cells within the tumor microenvironment.
Conclusions:
- Understanding STIM1's role in diverse tumor cell death pathways is vital for identifying new therapeutic targets.
- Targeting STIM1 presents promising prospects for developing novel antitumor therapies.
- STIM1's regulation of immune cells highlights its broader impact on cancer progression.
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