Related Experiment Video
Updated: Jul 11, 2025
Assessing Cell Viability and Death in 3D Spheroid Cultures of Cancer Cells
Published on: June 16, 2019
STIM1 in tumor cell death: angel or devil?
Ran Ren1, Yongsheng Li2,3
1Chongqing University Cancer Hospital, School of Medicine, Chongqing University, 400044, Chongqing, China.
Abstract:
Stromal interaction molecule 1 (STIM1) is involved in mediating the store-operated Ca2+ entry (SOCE), driving the influx of the intracellular second messenger calcium ion (Ca2+), which is closely associated with tumor cell proliferation, metastasis, apoptosis, autophagy, metabolism and immune processes. STIM1 is not only regulated at the transcriptional level by NF-κB and HIF-1, but also post-transcriptionally modified by miRNAs and degraded by ubiquitination. Recent studies have shown that STIM1 or Ca2+ signaling can regulate apoptosis, autophagy, pyroptosis, and ferroptosis in tumor cells and act discrepantly in different cancers. Furthermore, STIM1 contributes to resistance against antitumor therapy by influencing tumor cell death. Further investigation into the mechanisms through which STIM1 controls other forms of tumor cell death could aid in the discovery of novel therapeutic targets. Moreover, STIM1 has the ability to regulate immune cells within the tumor microenvironment. Here, we review the basic structure, function and regulation of STIM1, summarize the signaling pathways through which STIM1 regulates tumor cell death, and propose the prospects of antitumor therapy by targeting STIM1.
Insights
Stromal interaction molecule 1 (STIM1) regulates calcium (Ca2+) signaling, impacting tumor cell death and immune responses. Targeting STIM1 offers potential for novel antitumor therapies by modulating these critical cancer processes.
Area of Science:
- Molecular Biology
- Cell Biology
- Cancer Research
Background:
- Stromal interaction molecule 1 (STIM1) is crucial for store-operated calcium (Ca2+) entry (SOCE).
- STIM1 influences key cancer processes including proliferation, metastasis, apoptosis, autophagy, metabolism, and immune responses.
- STIM1 is regulated transcriptionally, post-transcriptionally by miRNAs, and via ubiquitination.
Purpose of the Study:
- To review the structure, function, and regulation of STIM1.
- To summarize STIM1-mediated signaling pathways in tumor cell death.
- To explore STIM1 as a therapeutic target for antitumor strategies.
Main Methods:
- Literature review of STIM1's role in cancer.
- Analysis of STIM1's involvement in various cell death pathways (apoptosis, pyroptosis, ferroptosis).
- Examination of STIM1's influence on the tumor microenvironment and therapy resistance.
Main Results:
- STIM1 and Ca2+ signaling differentially regulate tumor cell death across various cancers.
- STIM1 contributes to resistance against antitumor therapies by affecting tumor cell death mechanisms.
- STIM1 modulates immune cells within the tumor microenvironment.
Conclusions:
- Understanding STIM1's role in diverse tumor cell death pathways is vital for identifying new therapeutic targets.
- Targeting STIM1 presents promising prospects for developing novel antitumor therapies.
- STIM1's regulation of immune cells highlights its broader impact on cancer progression.
More Related Videos
06:38A Three-dimensional Model of Spheroids to Study Colon Cancer Stem Cells
Published on: January 22, 2021
19:44Enhancement of Apoptotic and Autophagic Induction by a Novel Synthetic C-1 Analogue of 7-deoxypancratistatin in Human Breast Adenocarcinoma and Neuroblastoma Cells with Tamoxifen
Published on: May 30, 2012
Related Concept Videos
01:17The Extrinsic Apoptotic Pathway
01:31The Intrinsic Apoptotic Pathway
02:23Abnormal Proliferation
02:40Cancer Stem Cells and Tumor Maintenance
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
01:19Interactions Between Signaling Pathways
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
02:38Mitogens and the Cell Cycle