Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Association Areas of the Cortex01:21

Association Areas of the Cortex

5.4K
Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
5.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Learning to select computations in recurrent neural circuits.

bioRxiv : the preprint server for biology·2026
Same author

Using economic value signals from primate prefrontal cortex in neuro-engineering applications.

Journal of neural engineering·2025
Same author

Orbitofrontal High-Gamma Reflects Spike-Dissociable Value and Decision Mechanisms.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2025
Same author

Orbitofrontal high-gamma reflects spike-dissociable value and decision mechanisms.

bioRxiv : the preprint server for biology·2024
Same author

Monkeys exhibit human-like gaze biases in economic decisions.

eLife·2023
Same author

Sleep to remember, sleep to forget: Rapid eye movement sleep can have inverse effects on recall and generalization of fear memories.

Neurobiology of learning and memory·2021
Same journal

Neural timescales from a computational perspective.

Nature neuroscience·2026
Same journal

Author Correction: Spinal cord Tau pathology induces tactile deficits and cognitive impairment in Alzheimer's disease via dysregulation of CCK neurons.

Nature neuroscience·2026
Same journal

Hippocampal theta sweeps indicate goal direction during navigation.

Nature neuroscience·2026
Same journal

Just how goal-directed are hippocampal theta sweeps, anyway?

Nature neuroscience·2026
Same journal

Goal-directed hippocampal theta sweeps during memory-guided navigation.

Nature neuroscience·2026
Same journal

Connectomic evidence that ordered activity drives neuromuscular network formation.

Nature neuroscience·2026
See all related articles

Related Experiment Video

Updated: Jul 11, 2025

Operant Protocols for Assessing the Cost-benefit Analysis During Reinforced Decision Making by Rodents
07:05

Operant Protocols for Assessing the Cost-benefit Analysis During Reinforced Decision Making by Rodents

Published on: September 10, 2018

6.0K

Behavioral read-out from population value signals in primate orbitofrontal cortex.

Vincent B McGinty1, Shira M Lupkin2,3

  • 1Center for Molecular and Behavioral Neuroscience, Rutgers University-Newark, Newark, NJ, USA. vince.mcginty@rutgers.edu.

Nature Neuroscience
|November 6, 2023
PubMed
Summary
This summary is machine-generated.

Variability in primate choices is explained by value signals from orbitofrontal cortex (OFC) neurons. This reveals how OFC neural activity translates into economic decisions, suggesting population-level read-out mechanisms.

More Related Videos

Performing Behavioral Tasks in Subjects with Intracranial Electrodes
12:10

Performing Behavioral Tasks in Subjects with Intracranial Electrodes

Published on: October 2, 2014

11.4K
Real-time fMRI Biofeedback Targeting the Orbitofrontal Cortex for Contamination Anxiety
10:51

Real-time fMRI Biofeedback Targeting the Orbitofrontal Cortex for Contamination Anxiety

Published on: January 20, 2012

21.3K

Related Experiment Videos

Last Updated: Jul 11, 2025

Operant Protocols for Assessing the Cost-benefit Analysis During Reinforced Decision Making by Rodents
07:05

Operant Protocols for Assessing the Cost-benefit Analysis During Reinforced Decision Making by Rodents

Published on: September 10, 2018

6.0K
Performing Behavioral Tasks in Subjects with Intracranial Electrodes
12:10

Performing Behavioral Tasks in Subjects with Intracranial Electrodes

Published on: October 2, 2014

11.4K
Real-time fMRI Biofeedback Targeting the Orbitofrontal Cortex for Contamination Anxiety
10:51

Real-time fMRI Biofeedback Targeting the Orbitofrontal Cortex for Contamination Anxiety

Published on: January 20, 2012

21.3K

Area of Science:

  • Neuroscience
  • Decision Neuroscience
  • Primate Neurophysiology

Background:

  • The primate orbitofrontal cortex (OFC) is implicated in value-based decision-making.
  • The precise neural mechanisms linking OFC value representations to behavioral choices remain unclear.

Purpose of the Study:

  • To elucidate the neural mechanisms by which the orbitofrontal cortex (OFC) influences economic decision-making.
  • To link trial-wise variability in choices to neural activity patterns within the OFC.

Main Methods:

  • Simultaneous recording of neural activity from multiple orbitofrontal cortex (OFC) neurons in non-human primates.
  • Decoding of value signals from OFC neural population activity.
  • Analysis of the relationship between decoded value signals and behavioral choices on a trial-by-trial basis.

Main Results:

  • Trial-by-trial variations in choices were significantly explained by variations in value signals decoded from OFC neural populations.
  • The observed neural-behavioral relationship aligns with a model where OFC activity projects from a low-dimensional value-encoding subspace to a behaviorally relevant output subspace.
  • This provides a mechanistic link between OFC value representations and decision outcomes.

Conclusions:

  • The study identifies a critical neural-behavioral link in the orbitofrontal cortex (OFC) for economic decision-making.
  • Findings suggest that population-level read-out mechanisms, similar to those in sensory and motor cortices, are employed by the OFC.
  • This work resolves longstanding questions regarding the OFC's role in economic choices.