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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Immune checkpoint analysis in ear cancer.

M Klein1, E Polgart2, C Hallermann3,4

  • 1Department of Oral & Maxillofacial Surgery, School of Medicine, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany. mauklein@ukaachen.de.

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|November 7, 2023
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Summary

Prognostic markers for ear squamous cell carcinoma (ecSCC) were evaluated. While CD8 and FoxP3 showed some correlation with disease-specific death, the tested markers are generally unsuitable for predicting outcomes in ecSCC.

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Area of Science:

  • Oncology
  • Immunology
  • Dermatopathology

Background:

  • Ear cutaneous squamous cell carcinoma (ecSCC) is a common cancer.
  • Locoregional lymph node metastasis occurs in 6-11% of ecSCC cases.
  • Predictive markers for ecSCC prognosis are needed.

Purpose of the Study:

  • To evaluate PD-L1, PD-1, CD4, CD8, and FoxP3 as prognostic markers for ecSCC.
  • To correlate marker expression with clinicopathological parameters.

Main Methods:

  • Immunohistochemical analysis of PD-L1, PD-1, CD4, CD8, and FOXP3 expression in 64 ecSCC patients.
  • Correlation with clinicopathological parameters including metastasis and disease progression.

Main Results:

  • Weak FoxP3 expression (p=0.003) and reduced CD8 expression (p=0.04) correlated with increased disease-specific death.
  • PD-L1 expression >1% was observed in 39.1% of patients.

Conclusions:

  • The markers CD4, CD8, FoxP3, PD-1, and PD-L1 are largely inappropriate for prognostic evaluation in ecSCC.
  • Further investigation of CD8 and FoxP3 in larger cohorts is warranted for prognostic potential.