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Updated: Jul 11, 2025
06:01
A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
Published on: August 18, 2015
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Heart rate turbulence in acute ischemic stroke
Helena Stengl1,2,3, Ramanan Ganeshan1,2, Regina von Rennenberg1,2,4
1Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
European Stroke Journal
|November 7, 2023
Summary
Heart rate turbulence (HRT) is a marker of autonomic cardiac regulation. Severely abnormal HRT in acute ischemic stroke patients is linked to greater disability and cardiac issues, but not mortality.
Area of Science:
- Cardiology
- Neurology
- Autonomic Function Testing
Background:
- Heart rate turbulence (HRT) is an ECG-based marker of autonomic cardiac regulation.
- HRT has prognostic value in cardiovascular diseases, but data in acute ischemic stroke patients is limited.
Purpose of the Study:
- To investigate the prognostic value of HRT in patients with acute ischemic stroke.
- To assess the association between HRT parameters and clinical outcomes, including functional outcome, mortality, atrial fibrillation, and myocardial fibrosis.
Main Methods:
- Holter-ECG recordings were analyzed for HRT parameters (turbulence onset and slope) in 335 acute ischemic stroke patients.
- HRT was categorized as normal, abnormal, or severely abnormal.
- Outcomes included modified Rankin Scale score, 1-year mortality, new atrial fibrillation, and cardiac MRI-detected myocardial fibrosis.
Main Results:
- Severely abnormal HRT was associated with increased disability (higher mRS) at 3 months (aOR: 2.9) and new atrial fibrillation (aOR: 3.5).
- Severely abnormal HRT was also linked to MRI-detected myocardial fibrosis (aOR: 5.8).
- No significant association was found between HRT categories and 1-year mortality; abnormal HRT was not linked to any analyzed outcomes.
Conclusions:
- Severely abnormal HRT is associated with increased disability and cardiac comorbidities in acute ischemic stroke patients.
- HRT may help identify patients needing further monitoring for atrial fibrillation and cardiac imaging.
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