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Related Experiment Video

Updated: Jul 11, 2025

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells
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Association between CD10 expression and phyllodes tumor: A retrospective case control study.

Fang Tian1, Jie Zhao1, Qing-Fang Shi1

  • 1Pathology Department, Gansu Provincial Maternity and Child-care Hospital, Lan Zhou, China.

Medicine
|November 7, 2023
PubMed
Summary
This summary is machine-generated.

This study found that CD10 expression, alongside histological features, can help differentiate phyllodes tumors (PT) from fibroadenomas (FA). CD10 may serve as a valuable marker for distinguishing these breast lesions.

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Area of Science:

  • Oncology
  • Pathology
  • Biomarkers

Background:

  • Phyllodes tumors (PT) and fibroadenomas (FA) are common breast tumors with overlapping histological features.
  • Accurate differentiation is crucial for appropriate patient management and treatment.
  • Immunohistochemical markers may aid in distinguishing between PT and FA.

Purpose of the Study:

  • To investigate the association between immunohistochemical markers and phyllodes tumors (PT).
  • To analyze differences in marker expression between various grades of PT and FA.
  • To identify potential markers for differentiating PT from FA.

Main Methods:

  • Retrospective case-control study of 69 patients (34 PT, 35 FA) from October 2014 to May 2021.
  • Analysis of histopathological characteristics and expression of CD10, CD117, CD34, P53, and Ki-67.
  • Multivariate analysis to determine independent associations with PT.

Main Results:

  • Increasing malignancy in PT correlated with ill-defined borders, heterogeneous stroma, and increased stromal cellularity/overgrowth (P < .05).
  • CD10 expression was independently associated with PT (OR = 0.67, P < .05).
  • Histological features and CD10 expression differed significantly between PT and FA grades.

Conclusions:

  • Histological features are important for differentiating PT and FA.
  • CD10 expression is independently associated with PT.
  • CD10 shows potential as a differentiation marker for phyllodes tumors.