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Update on Management and Outcomes of Congenital Diaphragmatic Hernia

K Taylor Wild1, Holly L Hedrick2,3, Anne M Ades1

  • 1Division of Neonatology, Children's Hospital of Philadelphia, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA, USA.

Journal of Intensive Care Medicine
|November 7, 2023
PubMed

Insights

Infants with congenital diaphragmatic hernia (CDH) require specialized multidisciplinary care. Despite advances, high mortality and morbidity persist, necessitating ongoing research and improved care pathways for these complex cases.

Area of Science:

  • Pediatric Surgery
  • Neonatology
  • Critical Care Medicine

Background:

  • Congenital diaphragmatic hernia (CDH) presents unique and complex challenges from fetal life through adulthood.
  • Despite specialized care at high-volume centers, including advanced ventilation and ECMO, mortality and morbidity remain high in affected infants.

Purpose of the Study:

  • To review the current literature on congenital diaphragmatic hernia (CDH) management.
  • To present a clinical care pathway for neonatal care and long-term follow-up of CDH patients.

Main Methods:

  • Literature review of existing studies on CDH.
  • Description of a multidisciplinary clinical care pathway for CDH management.

Main Results:

  • Multidisciplinary teams experienced in CDH care are crucial for improving outcomes.
  • Current advanced strategies have not fully mitigated the high mortality and morbidity rates.

Conclusions:

  • Continued advancements in care pathways are essential to further reduce CDH mortality.
  • Improving long-term morbidity for CDH survivors is a critical area for ongoing clinical focus and research.

Keywords:
congenital diaphragmatic herniaextracorporeal membrane oxygenationpulmonary hypertension

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