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Related Experiment Video

Updated: Jul 11, 2025

Author Spotlight: Unveiling the Pathway Linking Obesity to Autoimmune Inflammation in Multiple Sclerosis
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The Association between Diet and Multiple Sclerosis.

Vahid Asgharzadeh1, Seyyed Amin Seyyed Rezaei2, Behroz Mahdavi Poor3

  • 1Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.

Endocrine, Metabolic & Immune Disorders Drug Targets
|November 7, 2023
PubMed
Summary

Fruit consumption in childhood may protect against multiple sclerosis (MS), while high intake of fats, processed foods, and sweets may increase risk. This study explored diet and MS in Iran.

Keywords:
Multiple sclerosisdietfast foodmeatprimary progressive PPMS.soybean

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Area of Science:

  • Neurology
  • Immunology
  • Nutritional Science

Background:

  • Multiple sclerosis (MS) is a chronic CNS autoimmune disease impacting young adults (20-40), with increasing global prevalence.
  • Both genetic predisposition and environmental influences are implicated in MS etiology.
  • Women exhibit a higher prevalence of MS compared to men.

Purpose of the Study:

  • To examine the association between dietary habits and MS in the Azeri population of Iran's East Azerbaijan province.
  • Investigate specific food consumption patterns linked to MS development in a defined demographic.

Main Methods:

  • A dietary demographic questionnaire was administered to 467 individuals diagnosed with MS and 260 healthy controls under 15 years of age.
  • Statistical analysis was performed to evaluate the relationship between reported food intake and MS status.

Main Results:

  • MS patients showed significantly higher consumption of fats, high-fat dairy, fast food, soybean, sausages, pickles, and leftover foods (p<0.0001).
  • Healthy individuals reported significantly higher fruit intake (p<0.0001).
  • Increased consumption of meat, sweets, and fizzy drinks was noted in MS patients (p<0.05), with no significant differences in vegetable, cake, biscuit, or spice intake.

Conclusions:

  • Childhood fruit consumption may confer a protective effect against developing MS.
  • Dietary factors such as high fat, processed foods, sweets, and certain meats consumed in childhood may represent risk factors for MS.