Related Experiment Video
Updated: Jul 11, 2025
13:38
Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells
Published on: January 18, 2017
12.3K
Caffeic Acid Phenethyl Ester: A Potential Therapeutic Cancer Agent?
Geir Bjørklund1, Olha Storchylo2, Massimiliano Peana3
1Council for Nutritional and Environmental Medicine (CONEM), Mo i Rana, Norway.
Current Medicinal Chemistry
|November 7, 2023
Summary
Caffeic acid phenethyl ester (CAPE), a propolis compound, shows promise in cancer treatment. Research indicates CAPE exhibits antitumor effects and warrants clinical trials for human cancer therapies.
Area of Science:
- Natural product chemistry
- Pharmacology
- Oncology
Background:
- Propolis and its key compound, caffeic acid phenethyl ester (CAPE), are recognized for anti-inflammatory properties and therapeutic potential.
- CAPE's biological activities are extensively studied for various applications.
Purpose of the Study:
- To review the potential of caffeic acid phenethyl ester (CAPE) in cancer treatment.
- To consolidate evidence on CAPE's antitumor effects and mechanisms.
Main Methods:
- A narrative review of scientific literature from 2000 to 2022.
- Searches conducted on PubMed and Web of Science using keywords related to cancer, CAPE, and propolis.
- Focus on studies detailing antitumor effects and mechanisms of CAPE.
Main Results:
- CAPE demonstrates broad biological benefits, including antimicrobial, antioxidant, antiviral, anti-inflammatory, and cytotoxic effects.
- Significant antitumor activities observed across various cancer cell lines, such as growth inhibition and apoptosis induction.
- CAPE exhibits anti-angiogenic properties and suppresses tumor invasiveness and malignancy.
Conclusions:
- Preclinical toxicity assessments suggest CAPE is a potential candidate for cancer therapy.
- Clinical trials are recommended to validate CAPE's efficacy and safety in human cancers.
- Further research is needed to fully understand CAPE's therapeutic benefits for diverse cancer types.
More Related Videos
12:00Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro
Published on: July 5, 2017
19.2K
09:03Establishment of Hepatocarcinoma in BALB/c-nu Mice and Investigation of the Therapeutic Effect of the Sanleng Jiashen Formula
Published on: January 26, 2024
387
Related Concept Videos
02:57Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K
02:38Mitogens and the Cell Cycle
6.5K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.5K
02:34Inhibition of Cdk Activity
4.8K
The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
4.8K
02:59Cancer Prevention
6.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.2K
02:50Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
02:49Cancer Therapies
7.7K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.7K