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Updated: Jul 11, 2025
12:55
Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care
Published on: February 16, 2015
21.4K
Adoptive cell therapy for cancer treatment
Shi Du1,2, Jingyue Yan1,2, Yonger Xue1,2
1Division of Pharmaceutics and Pharmacology College of Pharmacy Ohio State University Columbus USA.
Exploration (Beijing, China)
|November 7, 2023
Summary
Adoptive cell therapy (ACT) activates a patient's immune cells to fight cancer. This review covers current ACT methods like tumor-infiltrating lymphocytes (TILs) and discusses their clinical potential and hurdles.
Area of Science:
- Immunology
- Oncology
- Biotechnology
Background:
- Adoptive cell therapy (ACT) is an emerging anti-cancer strategy.
- ACT involves ex vivo immune cell activation and reinfusion for cancer elimination.
Purpose of the Study:
- To introduce representative ACT approaches.
- To discuss opportunities and challenges for ACT clinical translation.
Main Methods:
- Review of current ACT modalities including tumor-infiltrating lymphocytes (TILs), genetically engineered immune cells, and dendritic cells (DCs) vaccines.
- Discussion of advancements in cell culture and genetic engineering techniques relevant to ACT.
Main Results:
- ACT is clinically utilized for hematological malignancies.
- Numerous ACT-based regimens are in various clinical trial phases.
Conclusions:
- ACT demonstrates significant promise in treating diverse cancer types.
- Further research and development are needed to overcome challenges in ACT clinical translation.
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