Direct arene trifluoromethylation enabled by promiscuous activity of fungal laccase
Yi Ling Goh1, Shi Yang Preston Long1, Mun Fei Eddy Wong1
1Institute of Sustainability for Chemicals, Energy and Environment (ISCE2), Agency for Science, Technology and Research (A*STAR), 8 Biomedical Grove, Neuros #07-01, Singapore 138665, Republic of Singapore. liu_zhennan@isce2.a-star.edu.sg.
Abstract:
Laccase from Trametes versicolor was found to oxidize non-phenolic arenes and enable the trifluoromethylation of arenes in the presence of in situ generated CF3 radicals at a catalyst loading as low as 0.0034%. The biocatalytic trifluoromethylation proceeded under mild conditions and could increase the yield by up to 12 fold, compared to the control.
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