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Human Ageing Genomic Resources: updates on key databases in ageing research
João Pedro de Magalhães1, Zoya Abidi2, Gabriel Arantes Dos Santos1
1Genomics of Ageing and Rejuvenation Lab, Institute of Inflammation and Ageing, University of Birmingham, Birmingham B15 2WB, UK.
Nucleic Acids Research
|November 7, 2023
Summary
The Human Ageing Genomic Resources (HAGR) provide a comprehensive, expert-curated collection of databases and tools for researchers studying ageing and longevity. These updated resources facilitate the exploration of genes, drugs, and genetic variants influencing the ageing process.
Area of Science:
- Genomics
- Aging Research
- Bioinformatics
Background:
- Aging is a complex biological process influenced by numerous factors.
- The Human Ageing Genomic Resources (HAGR) have been a valuable tool for aging research for 20 years.
- Continuous updates and expert curation are essential for maintaining accurate and relevant aging research databases.
Purpose of the Study:
- To present the key features and recent enhancements of the Human Ageing Genomic Resources (HAGR).
- To highlight the utility of HAGR's six integrated databases for studying aging, longevity, and related interventions.
- To provide researchers with updated, curated data on genes, drugs, and genetic variants associated with aging.
Main Methods:
- Compilation and curation of data from scientific literature.
- Integration of six specialized databases: GenAge, AnAge, DrugAge, GenDR, CellAge, and LongevityMap.
- Development of tools and meta-analyses for gene expression signatures related to aging processes.
Main Results:
- HAGR includes GenAge (307 human aging genes, 2205 model organism genes), AnAge (4645 species), DrugAge (1097 compounds), GenDR (214 genes), CellAge (866 genes), and LongevityMap (3144 variants).
- Databases are integrated, regularly updated, and manually curated by experts.
- HAGR offers tools and meta-analyses for gene expression signatures of aging, dietary restriction, and senescence.
Conclusions:
- HAGR provides a robust, freely accessible online resource for the scientific community.
- The integrated and curated databases significantly aid research into the genetic and molecular underpinnings of aging.
- Ongoing updates ensure HAGR remains a vital platform for advancing the understanding and manipulation of aging.
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