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Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease
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Diagnostic value of circRNA in coronary heart disease: a meta-analysis

Ming-Zhu Li1, Jia-Nan Zhang2, Fei Ren1

  • 1Department of Cardiology, The First People's Hospital of Lianyungang, Lianyungang, 222002, Jiangsu PR, China.

Biomarkers in Medicine
|November 7, 2023
PubMed

Insights

Circular RNAs (circRNAs) show promise as diagnostic biomarkers for coronary heart disease (CHD). This meta-analysis confirms their potential, with a pooled area under the curve of 0.80 for CHD diagnosis.

Area of Science:

  • Biomarkers and Diagnostics
  • Cardiovascular Research
  • Molecular Biology

Background:

  • Circular RNAs (circRNAs) are increasingly recognized for their roles in various diseases.
  • Previous studies suggest circRNAs may aid in diagnosing coronary heart disease (CHD), but their diagnostic efficacy is inconsistent.
  • A comprehensive assessment is needed to evaluate the diagnostic value of circRNAs for CHD.

Conclusions:

  • Circular RNAs demonstrate potential as effective biomarkers for the diagnosis of coronary heart disease (CHD).
  • The findings support the utility of circRNAs in clinical settings for CHD diagnosis.

Keywords:
circRNAcoronary heart diseasediagnosismeta-analysis

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