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The Slate turkey: a model for secondary angle closure glaucoma.

A W de Kater, J R Smyth, R C Rosenquist

    Investigative Ophthalmology & Visual Science
    |December 1, 1986
    PubMed
    Summary

    An inherited eye disease causing secondary angle closure glaucoma was found in Slate turkeys. This condition, more severe in females, progresses from inflammation to significant intraocular pressure elevation.

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    Area of Science:

    • Ophthalmology
    • Veterinary Medicine
    • Genetics

    Background:

    • An inherited eye disease causing secondary angle closure glaucoma has been identified in turkeys.
    • The condition affects the Slate variety of Meleagris gallopavo.

    Purpose of the Study:

    • To describe the clinical and pathological characteristics of this inherited glaucoma in turkeys.
    • To investigate the progression and sex-influenced expression of the disease.

    Main Methods:

    • Clinical observation of affected turkeys.
    • Ophthalmic examination to assess disease progression.
    • Pathological examination of ocular tissues.

    Main Results:

    • The disease initiates with aqueous flare and posterior synechiae, leading to pupillary block and iris bombé.
    • Corneal edema, Descemet's membrane breaks, and buphthalmos develop subsequently.
    • Elevated intraocular pressure (IOP) is a late-stage finding, occurring after complete iris bombé. Disease expression is sex-influenced, with females showing more severe pathology.

    Conclusions:

    • This inherited condition in Slate turkeys mimics human angle closure glaucoma.
    • The sex-influenced nature of the disease warrants further investigation into genetic factors.
    • Understanding this model can provide insights into similar ocular conditions.

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