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Cells of the Adaptive Immune Response

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...

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Related Experiment Video

Updated: Jul 11, 2025

Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood

Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood

Published on: April 16, 2012

Unveiling the immune system aging in single-cell resolution.

Chun Lai Chan^1,2, Ryohichi Sugimura^1,3

¹School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Laboratory Block, 21 Sassoon Road, Pokfulam, Hong Kong SAR, China.

Journal of Leukocyte Biology

|November 7, 2023

Summary

This summary is machine-generated.

This commentary analyzes aging regulatory T cells in mice, detailing their spatial-temporal dynamics and receptor-ligand interactions. Understanding these changes offers insights into age-related diseases and potential therapies.

Keywords:

B lymphocytes T helper T lymphocytes T-reg cytotoxic T cells

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Last Updated: Jul 11, 2025

Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood

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Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Published on: June 26, 2018

Area of Science:

Immunology
Aging Research
Computational Biology

Background:

Regulatory T cells (Tregs) play a crucial role in immune homeostasis.
Aging is associated with significant alterations in immune cell function and dynamics.
Understanding Treg behavior during aging is vital for addressing age-related immune dysfunction.

Purpose of the Study:

To critically analyze the spatial-temporal dynamics of aging Tregs.
To investigate potential receptor-ligand interactions influencing Treg function in aging mice.
To propose future research directions for understanding Treg aging.

Main Methods:

Analysis of Treg populations in mice of different ages (3, 18, 24 months) using the Tabula Muris Senis dataset.
Examination of Tregs in specific anatomical niches (lymph nodes, bone marrow).
In silico identification of potential receptor-ligand interactions (e.g., calmodulin/Fas, PSGL-1/L-selectin).

Main Results:

Detailed spatial-temporal dynamics of Tregs across different ages and anatomical locations.
Identified potential receptor-ligand interactions involving T follicular regulatory cells, T follicular helper cells, and germinal center B cells.
Highlighted the significance of aging Tregs in immune regulation.

Conclusions:

Aging Tregs exhibit distinct spatial-temporal dynamics and interaction profiles.
Further research into Treg aging mechanisms may reveal therapeutic targets for age-related diseases.
This commentary provides a critical analysis and future directions for Treg aging studies.