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Transient hyperphosphatasemia of infancy
Helvetica Paediatrica Acta
|October 1, 1986
Insights
Transient hyperphosphatasemia of infancy (THI) is a common, benign condition in children. It often occurs in healthy infants and those with other disorders, with uniformly normal development, suggesting avoidance of invasive diagnostics.
Area of Science:
- Pediatrics
- Biochemistry
Background:
- Transient hyperphosphatasemia of infancy (THI) is a biochemical finding.
- Its prevalence and association with various clinical conditions are not fully understood.
Purpose of the Study:
- To describe cases of THI.
- To compare these cases with existing literature.
- To evaluate the clinical significance and management of THI.
Main Methods:
- Case series description.
- Literature review and comparison.
Main Results:
- Six cases of THI were identified and analyzed.
- THI is potentially more prevalent than previously recognized.
- The condition can manifest in both healthy children and those with underlying disorders.
Conclusions:
- THI is a benign condition with a uniformly normal developmental outcome.
- Invasive diagnostic procedures are unnecessary for THI.
- Recognition of THI's benign nature can prevent unnecessary medical interventions.
Abstract:
Six patients with transient hyperphosphatasemia of infancy (THI) are described and compared to similar cases reported in the literature. THI appears to be more common than usually thought and may occur in healthy children as well as in patients with various clinical disorders. The evolution of such children seems uniformly normal. Invasive diagnostic procedures should therefore be avoided in this benign condition.