Basal Cell Skin Cancer, Version 2.2024, NCCN Clinical Practice Guidelines in Oncology

Area of Science:

• Oncology
• Dermatology
• Public Health

Background:

• Basal cell carcinoma (BCC) is the most prevalent form of skin cancer in the U.S.
• Estimated 2 million Americans are affected annually, with incidence rates increasing.
• Radiation exposure (sunlight, medical therapy) is a primary risk factor for BCC development.

Purpose of the Study:

• To summarize current incidence estimates for Basal cell carcinoma.
• To review the etiology and risk factors associated with BCC.
• To present updated risk stratification and treatment guidelines for BCC.

Main Methods:

• Review of epidemiological data for BCC incidence estimation.
• Analysis of factors contributing to BCC development.
• Summary of NCCN Clinical Practice Guidelines in Oncology for BCC management.

Main Results:

• BCC incidence is high and rising, with an estimated 2 million cases annually in the U.S.
• Radiation exposure is a significant etiological factor.
• While BCC has a low metastatic potential, treatment considerations include potential disfigurement and functional limitations.

Conclusions:

• Updated NCCN Guidelines provide a framework for risk stratification and treatment of BCC.
• Management of BCC requires consideration of its high incidence, risk factors, and potential treatment sequelae.
• Continued monitoring and research are essential for addressing the rising incidence of Basal cell carcinoma.