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Rethinking NBM DBS: Intermittent stimulation improves sustained attention in Parkinson's disease

Sanskriti Sasikumar1, Melanie Cohn2, Ariana Youm2

  • 1Division of Neurology, University of Toronto, Toronto, Ontario, Canada; Edmond J. Safra Program in Parkinson's Disease and Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital, UHN, Toronto, Ontario, Canada.

Brain Stimulation
|November 7, 2023
PubMed
Abstract

No abstract available in PubMed .

Keywords:
Cognitive impairmentDeep brain stimulationIntermittent stimulationNucleus basalis of meynertParkinson's disease

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Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
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