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Cutaneous malignant lymphoma.

B A Esche, P J Fitzpatrick

    International Journal of Radiation Oncology, Biology, Physics
    |December 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Cutaneous non-Hodgkin's lymphoma (NHL) is rare. Radiotherapy effectively treats localized skin NHL, offering good survival rates, while disseminated disease requires systemic therapy.

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    Area of Science:

    • Oncology
    • Dermatology
    • Hematology

    Background:

    • Cutaneous non-Hodgkin's lymphoma (NHL) is an uncommon presentation.
    • This study reviewed 61 patients diagnosed between 1967-1982.
    • Lymphoma was confined to the skin in 43 of these patients.

    Purpose of the Study:

    • To analyze the clinical characteristics, prognostic factors, and treatment outcomes for patients with cutaneous NHL.
    • To evaluate the efficacy of radiotherapy versus systemic therapy for different stages of skin lymphoma.

    Main Methods:

    • Retrospective analysis of 61 evaluable patients with non-Hodgkin's lymphoma.
    • Categorization of patients based on disease extent (confined to skin vs. disseminated).
    • Assessment of prognostic indicators including tumor site, bulk, and histological subtype.

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    Main Results:

    • Diffuse histiocytic tumors represented 46% of cases.
    • Overall 5-year survival was 52%.
    • Patients with disease confined to the skin had significantly better 5-year (62%) and 10-year (57%) survival rates and a median survival of 159 months compared to those with disseminated disease (median survival 18 months).
    • Radiotherapy achieved local control in all patients with small bulk localized tumors, with over 80% five-year relapse-free rate.
    • Tumor site and bulk were significant prognostic indicators, but histological subtype was not.

    Conclusions:

    • Lymphomas confined to the skin can be effectively treated with radiotherapy.
    • Disseminated cutaneous lymphoma necessitates systemic therapy.
    • The optimal management for bulky cutaneous lymphoma remains an area for further investigation.