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[Benchmark dose estimation of polycyclic aromatic hydrocarbons exposure base on Bayesian kernel machine regression].

Q Q Wang1, J Cui1, C Zhang2

  • 1Department of Health Statistics, School of Public Health, Shanxi Medical University, Taiyuan 030001, China.

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi = Zhonghua Laodong Weisheng Zhiyebing Zazhi = Chinese Journal of Industrial Hygiene and Occupational Diseases
|November 7, 2023
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Summary

Polycyclic aromatic hydrocarbons (PAHs) exposure, particularly hydroxylated PAHs (OH-PAHs), significantly increases the risk of red blood cell damage in non-occupational populations. Low-concentration OH-PAH exposure is more sensitive, necessitating strict control of PAH doses.

Keywords:
Bayesian kernel machine regressionBenchmark doseJoint effectPolycyclic aromatic hydrocarbonsRed blood cell

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Area of Science:

  • Environmental Health
  • Toxicology
  • Biostatistics

Context:

  • Adult residents near a coking plant were studied to assess exposure to polycyclic aromatic hydrocarbons (PAHs).
  • Biomonitoring included blood and urine analysis to detect routine parameters and creatinine.
  • Previous research indicates potential health risks associated with PAH exposure in industrial areas.

Purpose:

  • To estimate benchmark doses (BMD) for PAHs using Bayesian kernel machine regression (BKMR).
  • To evaluate the combined effects of hydroxylated PAHs (OH-PAHs) on red blood cell damage.
  • To determine acceptable exposure limits for OH-PAHs in a non-occupational population.

Summary:

  • Higher OH-PAH concentrations in red blood cells correlated with abnormal red blood cell counts.
  • 2-hydrol-naphthalene was identified as a major contributor to OH-PAH combined effects (PIP=0.9354).
  • Increased OH-PAH mixture concentrations elevated the risk of red blood cell abnormalities, with low concentrations showing higher sensitivity.

Impact:

  • Identified specific acceptable doses for eight OH-PAHs, with 2-hydrol-naphthalene at 1.010 μmol/mol Cr.
  • Established that OH-PAH mixtures have a combined effect on red blood cell damage.
  • Recommended controlling total PAH exposure dose within 1 μmol/mol Cr to mitigate health risks.