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Updated: Jul 11, 2025

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
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Mendelian randomization for cardiovascular diseases: principles and applications

Susanna C Larsson1,2, Adam S Butterworth3,4,5,6,7, Stephen Burgess3,4,8

  • 1Unit of Medical Epidemiology, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.

European Heart Journal
|November 7, 2023
PubMed
Summary

Mendelian randomization (MR) uses genetic variants to strengthen causal evidence for cardiometabolic risk factors. This approach improves understanding of disease links and drug efficacy in cardiovascular epidemiology.

Keywords:
Cardiovascular diseaseGeneticsMendelian randomizationSingle nucleotide polymorphisms

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