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Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
Published on: November 20, 2015
Neurodevelopmental outcomes in preterm or low birth weight infants with germinal matrix-intraventricular hemorrhage:
Meicen Zhou1,2, Shaopu Wang1,2, Ting Zhang1,2
1Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, 610041, Sichuan Province, China.
Insights
Intraventricular hemorrhage (IVH) in preterm or low birth weight infants is linked to adverse neurodevelopmental outcomes. Increased IVH severity correlates with higher risks of impairment, motor delays, and cognitive deficits.
Area of Science:
- Neonatalogy
- Neurodevelopmental Pediatrics
- Perinatal Medicine
Background:
- Intraventricular hemorrhage (IVH) is a common complication in preterm and low birth weight (LBW) infants.
- The severity of IVH can significantly impact infant neurodevelopmental outcomes.
- Understanding these prognoses is crucial for early intervention strategies.
Conclusions:
- Adverse neurodevelopmental outcomes are positively associated with the occurrence and severity of IVH in preterm or LBW infants.
- These findings underscore the importance of predicting neurodevelopmental outcomes for timely clinical interventions.
- Identifying specific developmental delays in children with IVH is essential for developing comprehensive support measures.
Background:
This meta-analysis aimed to identify the near- and long-term neurodevelopmental prognoses of preterm or low birth weight (LBW) infants with different severities of intraventricular hemorrhage (IVH).
Methods:
Four databases were searched for observational studies that were qualified using the Newcastle-Ottawa Scale.
Results:
37 studies involving 32,370 children were included. Compared to children without IVH, children with mild IVH had higher incidences of neurodevelopmental impairment (NDI), cerebral palsy (CP), motor/cognitive delay, hearing impairment and visual impairment, as well as lower scores of the mental development index (MDI) and psychomotor development (PDI). Moreover, compared to mild IVH, severe IVH increased susceptibilities of children to NDI, motor delay, CP, hearing impairment and visual impairment, with worse performances in MDI, PDI, motor score and IQ. Mild IVH was not associated with seizures or epilepsy.
Conclusions:
Adverse neurodevelopmental outcomes positively associated with the occurrence and severity of IVH in preterm or LBW infants, providing evidence for counseling and further decisions regarding early therapeutic interventions.
Impact:
Adverse neurodevelopmental outcomes later in life were closely associated with the occurrence and severity of IVH in preterm or LBW infants. Our results highlight the importance to make prediction of the neurodevelopmental outcomes of children born preterm or LBW with a history of IVH, which will guide affected parents when their children need clinical interventions to reach the full potential. We emphasize the importance of identifying specific developmental delays that may exist in children with IVH, providing detailed information for the development of comprehensive intervention measures.
