Related Experiment Video

Updated: Jul 11, 2025

Highly Efficient Ligation of Small RNA Molecules for MicroRNA Quantitation by High-Throughput Sequencing
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Highly Efficient Ligation of Small RNA Molecules for MicroRNA Quantitation by High-Throughput Sequencing

Published on: November 18, 2014

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Insights into the structure and function of the RNA ligase RtcB.

Matthieu Moncan1,2, Hassan Rakhsh-Khorshid1,2, Leif A Eriksson3

  • 1Apoptosis Research Centre, University of Galway, Galway, Ireland.

Cellular and Molecular Life Sciences : CMLS
|November 7, 2023
PubMed
Summary

RtcB is the sole 3'-5' RNA ligase in humans, crucial for RNA splicing and maturation. This review explores RtcB structure, function, and regulation across species, highlighting its role in human cancer.

Keywords:
3′–5′ RNA ligaseArcheaseCancerCrystal structureRNA 2′,3′-cyclic phosphate and 5′-OH ligase [RtcB]RNA ligationTransfer RNA [tRNA]Unfolded protein response [UPR]X-box-binding protein 1 [XBP1]tRNA ligase complex

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