Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Personality Disorders: Paranoid and Schizoid01:22

Personality Disorders: Paranoid and Schizoid

48
Personality disorders represent enduring cognition, affect, and behavior patterns that significantly deviate from societal norms. These maladaptive traits often lead to difficulties in various domains, including interpersonal relationships, occupational settings, and overall psychological well-being. Paranoid personality disorder and schizoid personality disorder are two distinct conditions marked by odd or eccentric behavior.
Paranoid Personality Disorder
Paranoid personality disorder is...
48
Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

92
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
92
Positive Symptoms Schizophrenia: Hallucinations and Delusions01:26

Positive Symptoms Schizophrenia: Hallucinations and Delusions

58
Schizophrenia is a complex psychiatric disorder characterized by a range of symptoms that significantly impact cognition, behavior, and emotional regulation. Among these, the positive symptoms stand out as they involve the addition or exaggeration of normal mental functions, deviating markedly from typical behavior and perception. Hallucinations and delusions are prominent positive symptoms, each profoundly affecting the individual's experience of reality.
Hallucinations
Hallucinations in...
58
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

690
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
690
Schizophrenia01:17

Schizophrenia

92
Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
92
Negative and Cognitive Symptoms of Schizophrenia01:30

Negative and Cognitive Symptoms of Schizophrenia

50
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
50

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Humoral Immune Correlates Analysis of Four Vaccines Against SARS-CoV-2 in Rhesus Macaques.

Research square·2026
Same author

Clarifying transfusion-associated graft-versus-host disease risk in modern Hodgkin lymphoma survivorship.

Transfusion·2026
Same author

Digital twins in healthcare: a comprehensive review and future directions.

Frontiers in digital health·2025
Same author

Delirium identification, prevention and management in intensive care units in England, Wales and Northern Ireland: a survey of practice.

Anaesthesia·2025
Same author

Clutter-Generating Phantom Material. Part I: Development of a Tunable, Acoustic Clutter-Generating Layer for Use With Ultrasound Tissue-Mimicking Phantoms.

Ultrasound in medicine & biology·2025
Same author

Ensuring patient access to gene therapies for rare diseases: Navigating reimbursement and coverage challenges.

Molecular therapy. Methods & clinical development·2025
Same journal

Disintegrating ipseity: a gerontological exegesis of Alzheimer's disease and relational identity in Alice Munro's fiction.

Philosophy, ethics, and humanities in medicine : PEHM·2026
Same journal

Reconfiguring institutional authority through Mood: a cross-cultural systemic functional analysis of Egyptian and American medical drama.

Philosophy, ethics, and humanities in medicine : PEHM·2026
Same journal

Docendo discimus: promoting patient personhood in clinical supervision - a critical phenomenological study of reciprocal professional formation in medicine.

Philosophy, ethics, and humanities in medicine : PEHM·2026
Same journal

Interpretation and the art of care- Gadamer's hermeneutics and physician wellbeing.

Philosophy, ethics, and humanities in medicine : PEHM·2026
Same journal

Humanity-based nursing care in the ICU: a descriptive qualitative study.

Philosophy, ethics, and humanities in medicine : PEHM·2026
Same journal

Exploring the moral status of cadavers through artificial intelligence: a thematic analysis of AI-based perspectives in anatomy education.

Philosophy, ethics, and humanities in medicine : PEHM·2026
See all related articles

Related Experiment Video

Updated: Jul 11, 2025

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
05:52

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis

Published on: November 21, 2013

15.0K

Conceptualizing a less paranoid schizophrenia.

James Long1, Rachel Hull2

  • 1Department of Psychology, Chestnut Hill College, 7113 Valley Avenue, Philadelphia, PA, 19128, USA. LongJ2@chc.edu.

Philosophy, Ethics, and Humanities in Medicine : PEHM
|November 8, 2023
PubMed
Summary
This summary is machine-generated.

Schizophrenia and related disorders are better understood as spectra, not distinct categories. This dimensional approach offers improved early detection and targeted treatments for these complex psychopathologies.

Keywords:
PsychosisSchizoidSchizophreniaSchizophrenia spectrum disordersSchizotypy

More Related Videos

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack
07:31

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack

Published on: May 15, 2020

7.1K
Investigating the Effects of Antipsychotics and Schizotypy on the N400 Using Event-Related Potentials and Semantic Categorization
12:00

Investigating the Effects of Antipsychotics and Schizotypy on the N400 Using Event-Related Potentials and Semantic Categorization

Published on: November 19, 2014

12.9K

Related Experiment Videos

Last Updated: Jul 11, 2025

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
05:52

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis

Published on: November 21, 2013

15.0K
Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack
07:31

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack

Published on: May 15, 2020

7.1K
Investigating the Effects of Antipsychotics and Schizotypy on the N400 Using Event-Related Potentials and Semantic Categorization
12:00

Investigating the Effects of Antipsychotics and Schizotypy on the N400 Using Event-Related Potentials and Semantic Categorization

Published on: November 19, 2014

12.9K

Area of Science:

  • Clinical Psychology
  • Psychopathology
  • Neuroscience

Background:

  • Schizophrenia remains poorly understood, characterized by stigma, poor outcomes, and conflicting conceptualizations.
  • Current diagnostic categories exhibit unstable borders, heterogeneity, and etiological gaps.
  • Existing models struggle with the complexity of schizophrenia spectrum disorders.

Purpose of the Study:

  • To propose a reconceptualization of schizophrenia spectrum disorders.
  • To address limitations of current categorical approaches.
  • To introduce a dimensional and cybernetic model for improved understanding and treatment.

Main Methods:

  • Synthesizing research and clinical experience.
  • Analyzing phenomenological, cognitive, and behavioral modalities.
  • Integrating psychodynamic and Five Factor personality models.
  • Examining biopsychosocial stress and trauma influences.

Main Results:

  • Schizophrenia spectrum disorders are best viewed as spectra of traits and reactions.
  • These spectra are rooted in normal personality and distress responses.
  • A dimensional and cybernetic model offers a more robust explanatory construct.

Conclusions:

  • Reconceptualizing schizophrenia as a spectrum resolves diagnostic instability and inaccuracy.
  • This dimensional approach facilitates early detection and intervention.
  • It enables more targeted and effective treatment strategies for schizophrenia spectrum disorders.